Research record
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201 publications found
Graphical abstract unavailableJournal article
Molecules · 2019 · 24(10) · 1996–1996(18)
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was …
Graphical abstract unavailableJournal article
ChemPhotoChem · 2019 · 3(12) · 1212–1218
A photo-flow Norrish-Yang cyclisation has been devised that delivers 3-hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemic…
Graphical abstract unavailableJournal article
Euro. J. Med. Chem. · 2019 · 166 · 243–245
Two series of boehmeriasin A analogs have been synthesized in short and high yielding processes providing derivatives differing either in the alkaloid's pentacyclic scaffold or its peripheral substitution pattern. These series have enabled, for the first ti…
Graphical abstract unavailableJournal article
Journal of Electronic Materials · 2019 · 49(3) · 1808–1818
For a single nano-optical material, it is difficult to possess high transmittance and adequately filter ultraviolet (UV) and infrared radiation (IR) simultaneously. Consequently, hybrid nano-optical materials comprising components of appropriate proportions f…
Graphical abstract unavailableJournal article
Molecules · 2019 · 24(22) · 4018–(1-32)
The syntheses of the title compounds demonstrate a privileged introduction of a nitroso (and a hydroxyl via the Baudisch reaction) group to an aromatic ring. These complexes first appeared in the literature as early as 1939, and a range of applications has …
Graphical abstract unavailableJournal article
Chem. Eng. Tech. · 2018 · 41(10) · 2014–2023
We report a robust continuous flow procedure for the synthesis of glycerol carbonate (2‐GLC) from green reagents glycerol and dimethyl carbonate (DMC), mediated by an inexpensive polymer‐supported base catalyst using methanol as co‐solvent. High conversion an…
Graphical abstract unavailableJournal article
Synthesis · 2018 · 50(4) · 753–759
An efficient entry into highly substituted cyclopentanones is presented based on functionalizing cyclopentenones by means of an aza-Michael reaction with different aniline nucleophiles. The excellent diastereoselectivity of this process is ascribed to H-bo…
Graphical abstract unavailableBook chapter
Flow Chemistry for the Synthesis of Heterocycles · 2018 · 187–236
Continuous flow processing approaches are having a significant impact on the way we devise and perform chemical synthesis. Flow chemistry has repeatedly demonstrated numerous improvements with respect to synthesis efficiency, process safety and ease of reacti…
Graphical abstract unavailableJournal article
React. Chem. Eng. · 2018 · 3 · 722–732
Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address wit…
Graphical abstract unavailableJournal article
Monatshefte für Chemie · 2018 · 150 · 11–19
A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with cor…
Graphical abstract unavailableJournal article
J. Org. Chem. · 2018 · 83 · 2647–2659
The acyloxyallylation of unprotected aldoses was first demonstrated more than a decade ago as a potentially elegant two-carbon homologation of reducing sugars (upon ozonolysis), however, its application in real case syntheses remained scarce. Following up o…
Graphical abstract unavailableJournal article
SynLett · 2018 · 29 · 2648–2654
A detailed account on the outcome of the thermal reaction between benzylidene phthalides and various amino acid derivatives is reported. It was discovered that the tricyclic pyrroles as previously described are not the products formed in these reactions. Inst…
