Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the archive and use research tags to move between publications and the group’s scientific programme.

Clear
Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

53 publications found for Route design and process chemistry

Cover of Data in Brief
Graphical abstract for Spectroscopic dataset of Hedione’s derivatives gathered during process development

Journal article

Spectroscopic dataset of Hedione’s derivatives gathered during process development

Sharley, J. S.; Gambacorta, G.; Pérez, A. M. C.; Ferri, E. E.; Miranda, A. F.; Quesada, J. S.; Baxendale, I. R.

Data in Brief · 2023 · 46 · 108801(1)–108801(24)

Synthetic and heterocyclic chemistryRoute design and process chemistry

The dataset of spectroscopic analysis performed on starting materials, intermediates, and products relating to the synthesis of Hedione are hereby presented. The data were acquired in Durham university during the period between October 2020 and September 2021…

Open DOIPDF
Cover of Euro. J. Med. Chem.
Graphical abstract for Development of α,7α-Dihydroxy-6α-ethyl-24-nor-5b-Cholan-23-Sulfate Sodium Salt (INT-767): Process Optimization, Synthesis and Characterization of Metabolites

Journal article

Development of α,7α-Dihydroxy-6α-ethyl-24-nor-5b-Cholan-23-Sulfate Sodium Salt (INT-767): Process Optimization, Synthesis and Characterization of Metabolites

Cerra, B.; Venturoni, F.; Souma, M.; Ceccarelli, G.; Lozza, A. M.; Passeri, D.; De Franco, F.; Baxendale, I. R.; Pellicciari, R.; Macchiarulo, A.; Gioiello, A.

Euro. J. Med. Chem. · 2022 · 242 · 114652(1)–114652(15)

Synthetic and heterocyclic chemistryRoute design and process chemistry

Estrogen deficiency derived from inhibition of estrogen biosynthesis is a typical condition of postmenopausal women and breast cancer (BCs) patients undergoing antihormone therapy. The ensuing increase in aldosterone levels is considered to be the major cause…

Open DOIPDF
Cover of Tetrahedron
Graphical abstract for Further Investigations into Imine-Mediated Formation of Allylic Nitro Compounds

Journal article

Further Investigations into Imine-Mediated Formation of Allylic Nitro Compounds

Sharley, J. S.; Gambacorta, G.; Collado Pérez, A. M.; Ferri, E. E.; Miranda, A. F.; Quesada, J. S.; Baxendale, I. R.

Tetrahedron · 2022 · 126 · 133058(1)–133058(14)

Synthetic and heterocyclic chemistryRoute design and process chemistry

Nitro alkanes are valuable starting materials for functionalisation via their corresponding anions as well as their transformation into other important groups such as ketones via the Nef reaction. Herein, we report a process development study for the construc…

Open DOIPDF
Cover of Applied Physics A
Graphical abstract for Tracking on crystallization process of doped metal oxide IATO to optimize solvothermal conditions

Journal article

Tracking on crystallization process of doped metal oxide IATO to optimize solvothermal conditions

Hu, T.; Ian R. Baxendale, I. R.; Su, Y.; Li, F.; Duan, S.; Zhang, Y.; Fan, H.

Applied Physics A · 2022 · 128 · 1–8

Route design and process chemistry

XRD (X-ray diffraction) pattern analysis can estimate approximate preparation condition values based on nanomaterials formation; however, these initial values can be further refined without additional experiments by combining DSC (Differential Scanning Calori…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Journal article

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta, G.; Sharley, J. S.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2021 · 17 · 1181–1312

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the p…

Open DOIPDF
Cover of Reactions
Graphical abstract for Benzo[1,2,3]dithiazole Compounds: A History of Synthesis and Their Renewed Applicability in Materials and Synthetic Chemistry, Originating from the Herz Reaction

Journal article

Benzo[1,2,3]dithiazole Compounds: A History of Synthesis and Their Renewed Applicability in Materials and Synthetic Chemistry, Originating from the Herz Reaction

A. J. Nicholls; I. R. Baxendale

Reactions · 2021 · 2 · 175–208

Synthetic and heterocyclic chemistryRoute design and process chemistry

The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although, with…

Open DOIPDF
Cover of Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series
Graphical abstract for Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Book chapter

Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Brocken, L.; Baxendale. I. R.

Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series · 2020 · Chapter 8 · 257–315

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

Although ionic polymerisations are a valuable methodology historically they are less widely used because they are considered capricious, requiring significantly more optimisation due to their sensitivity to the specific reaction and processing conditions. …

PDF
Cover of J. Org. Chem.
Graphical abstract for Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

Journal article

Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

Ruggeri, M.; Dombrowski, A. W.; Djuric, S. W.; Baxendale, I. R.

J. Org. Chem. · 2020 · 85 · 7276–7286

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A novel rearrangement sequence of 3-hydroxyazetidines via a Ritter initiated cascade provides highly substituted 2-oxazolines in high yields. The reaction conditions and substrate scope of the transformation have been studied demonstrating the generality of t…

Open DOIPDF
Cover of ChemPhotoChem
Graphical abstract for Photochemical flow synthesis of 3-hydroxyazetidines

Journal article

Photochemical flow synthesis of 3-hydroxyazetidines

Ruggeri, M.; Dombrowski, A. W.; Djuric, S. W.; Baxendale, I. R.

ChemPhotoChem · 2019 · 3(12) · 1212–1218

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringPhotochemistry

A photo-flow Norrish-Yang cyclisation has been devised that delivers 3-hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemic…

Open DOIPDF
Cover of Journal of Electronic Materials
Graphical abstract for The Design and Preparation of Transparent Hybrid Composite Thin Films with Excellent Optical Properties and Improved Thermal Insulation by Optimized Combination of Nanomaterials

Journal article

The Design and Preparation of Transparent Hybrid Composite Thin Films with Excellent Optical Properties and Improved Thermal Insulation by Optimized Combination of Nanomaterials

Hu, T.; Su, Y.; Baxendale, I. R.; Zhang, Y.; Zhu, J.

Journal of Electronic Materials · 2019 · 49(3) · 1808–1818

Route design and process chemistryPhotochemistry

For a single nano-optical material, it is difficult to possess high transmittance and adequately filter ultraviolet (UV) and infrared radiation (IR) simultaneously. Consequently, hybrid nano-optical materials comprising components of appropriate proportions f…

Open DOIPDF
Cover of Molecules
Graphical abstract for The Synthesis and Utility of Metal-Nitrosophenolato Compounds—Highlighting the Baudisch Reaction

Journal article

The Synthesis and Utility of Metal-Nitrosophenolato Compounds—Highlighting the Baudisch Reaction

Nicholls, A. J.; Thomas Barber, T.; Baxendale, I. R.

Molecules · 2019 · 24(22) · 4018–(1-32)

Synthetic and heterocyclic chemistryRoute design and process chemistry

The syntheses of the title compounds demonstrate a privileged introduction of a nitroso (and a hydroxyl via the Baudisch reaction) group to an aromatic ring. These complexes first appeared in the literature as early as 1939, and a range of applications has …

Open DOIPDF
Cover of Flow Chemistry for the Synthesis of Heterocycles
Graphical abstract for Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Book chapter

Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Baumann, M.; Baxendale, I. R.

Flow Chemistry for the Synthesis of Heterocycles · 2018 · 187–236

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Continuous flow processing approaches are having a significant impact on the way we devise and perform chemical synthesis. Flow chemistry has repeatedly demonstrated numerous improvements with respect to synthesis efficiency, process safety and ease of reacti…

Open DOI