Research record
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201 publications found
Journal article
Reactions · 2021 · 2 · 175–208
The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although, with…
Journal article
PLoS Comput. Biol. · 2021 · 17(11) · e1009171-1–34
Predictive approaches such as virtual screening have been used in drug discovery with the objective of reducing developmental time and costs. Current machine learning and networkbased approaches have issues related to generalization, usability, or model int…
Journal article
J. Org. Chem. · 2021 · 86 · 13402–13419
We have prepared a library of functionalized quinolines through the magnesiation of 7-chloroquinolines under mild conditions, employing both batch and continuous flow conditions. The preparation involved the generation of mixed lithium-magnesium intermediat…
Journal article
Molecules · 2020 · 25 · 2160–2160(14)
The hydroxy-pyrazole and 3-hydroxy oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure fo…
Book chapter
Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series · 2020 · Chapter 8 · 257–315
Although ionic polymerisations are a valuable methodology historically they are less widely used because they are considered capricious, requiring significantly more optimisation due to their sensitivity to the specific reaction and processing conditions. …
Journal article
Synlett · 2020 · 19 · 1907–1912
The nitrosation of several alkanes using tert-butyl nitrite has been performed in flow showing a remarkable reduction in the reaction time compared with batch processing. Due to the necessity for large excesses of the alkane component a continuous recyclin…
Book chapter
Flow Chemistry: Integrated Approaches for Practical Applications · 2020 · Chapter 7 · 217–256
Polymers are an important class of compounds used in many commercial products; for example, in the aerospace and automotive industries functioning as low weight construction parts and seals, through into the packaging of food and drink and even as aqueous s…
Journal article
J. Org. Chem. · 2020 · 85 · 7276–7286
A novel rearrangement sequence of 3-hydroxyazetidines via a Ritter initiated cascade provides highly substituted 2-oxazolines in high yields. The reaction conditions and substrate scope of the transformation have been studied demonstrating the generality of t…
Journal article
Front. Chem. · 2020 · 8 · 1–7
Bacterial lipopolysaccharides (LPS) are important bio-medical structures, playing a major role in the interaction with human immune systems. Their core regions, containing multiple units of L-glycero-D-manno heptoses (L,D-heptose), are highly conserved struct…
Journal article
Euro. J. Org. Chem. · 2019 · X · 5424–5433
The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product have been facilitated by the use of flow chemistry techniques and immobilised reagents. Us…
Journal article
Chem. Commun. · 2019 · 55 · 2916–2919
A new catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid to derive a efficient heterogeneous direct amidation catalyst. The catalyst shows wide substrate applicability and higher levels of reactivity than the equivalent…
Journal article
Molecules · 2019 · 24(22) · 4154–(1-19)
A simple protocol yielding ortho-substituted nitrosophenols from phenols is demonstrated, in the form of copper(II) bis(nitrosophenolato) complexes. The developed methodology was applied to a range of substrates, confirming the role of the copper in both the …
