Baxendale GroupAdvanced synthetic chemistry, engineered for scale Department of Chemistry

Research record

Publications

Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.

201 publications found

Cover of Beilstein J. Org. Chem.
Graphical abstract for A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimicGraphical abstract unavailable

Journal article

A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.

Beilstein J. Org. Chem. · 2017 · 13 · 2549–2560

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described a…

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Cover of Euro. J. Org. Chem.
Graphical abstract for A Continuous Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of New Etomidate DerivativesGraphical abstract unavailable

Journal article

A Continuous Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of New Etomidate Derivatives

Baumann, M.; Baxendale, I. R.

Euro. J. Org. Chem. · 2017 · 44 · 6518–6524

A simple yet robust flow set-up for the efficient desulfurization of a series of thioimidazoles is presented generating the corresponding imidazole derivatives in high yields. The strategic choice of peristaltic over piston pumps allowed reliable delivery of …

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Cover of Biorg. Med. Chem.
Graphical abstract for A continuous flow synthesis and derivatization of 1,2,4-thiadiazolesGraphical abstract unavailable

Journal article

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

Baumann, M.; Baxendale, I. R.

Biorg. Med. Chem. · 2017 · 25 · 6218–6223

A continuous flow process is presented that enables the efficient synthesis and derivatization of 1,2,4-thiadiazole heterocycles. Special attention was given to the safe handling of the versatile yet hazardous trichloromethane sulfenylchloride reagent includi…

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Cover of Curr. Appl. Phys.
Graphical abstract for Adjust band gap of IATO nanoparticles to obtain desirable optical property by one-step hydrothermal oxidationGraphical abstract unavailable

Journal article

Adjust band gap of IATO nanoparticles to obtain desirable optical property by one-step hydrothermal oxidation

Hu, T.; Su, Y.; Baxendale, I. R.; Tan, J.; Tang, H.; Xiao, L.; Zheng, F.; Ning, P.

Curr. Appl. Phys. · 2017 · 1 · 584–591

Antimony-tin-doped indium oxide (IATO) as transparent conducting oxide (TCO) exhibits significant optical property on blocking UV and Infrared(IR) for wavelengths less ∼400 nm and over ∼1400 nm as well as appropriate transmissivity on visible wavelength in ou…

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Cover of React. Chem. Eng.
Graphical abstract for Continuous flow synthesis of poly(acrylic acid) via free radical polymerisationGraphical abstract unavailable

Journal article

Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

Brocken, L.; Price, P. D.; Whittaker, J.; Baxendale, I. R.

React. Chem. Eng. · 2017 · 2 · 662–668

The free radical polymerisation of aqueous solutions of acrylic acid (1) has been studied using a continuous flow reactor to quickly screen reaction parameters such as temperature, residence time, monomer- and initiator concentration. The experimental data …

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Cover of Molbank
Graphical abstract for Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2- carboxylateGraphical abstract unavailable

Journal article

Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2- carboxylate

Baumman, M.; Baxendale, I. R.

Molbank · 2017 · M951

This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and…

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Cover of Euro. J. Org. Chem.
Graphical abstract for Flow-Assisted Synthesis: A Key Fragment of SR 142948AGraphical abstract unavailable

Journal article

Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Kitching, M. O.; Dixon, O. E.; Baumann, M.; Baxendale, I. R.

Euro. J. Org. Chem. · 2017 · 44 · 6540–6553

We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise diffi…

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Cover of React. Chem. Eng.
Graphical abstract for Purification of poly(acrylic acid) using a membrane ultra-filtration unit in flowGraphical abstract unavailable

Journal article

Purification of poly(acrylic acid) using a membrane ultra-filtration unit in flow

Brocken, L.; Price, P. D.; Whittaker, J.; Baxendale, I. R.

React. Chem. Eng. · 2017 · 2 · 656–661

We have developed methodology to synthesise aqueous soluble polymers such as poly(acrylic acid) in flow, enabling access to a variety of molecular weights. However, full conversion was hard to achieve without increasing the dispersity and therefore purificat…

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Cover of Molbank
Graphical abstract for Rac-20,3a,6,6,60,60-Hexamethyl-3a,3b,6,7-tetrahydrospiro-[ benzo[2,3]cyclopropa[1,2-c]pyrazole- 1,10-cyclo-hepta[2,4]diene]Graphical abstract unavailable

Journal article

Rac-20,3a,6,6,60,60-Hexamethyl-3a,3b,6,7-tetrahydrospiro-[ benzo[2,3]cyclopropa[1,2-c]pyrazole- 1,10-cyclo-hepta[2,4]diene]

Baumann, M.; Lapraille, S.; Baxendale, I. R.

Molbank · 2017 · M948

This note describes a novel reaction cascade in which a tosylhydrazone derivative of eucarvone undergoes a non-classical dimerization process under basic conditions. The key step in this sequence is a dipolar cycloaddition between a diazo species and a tran…

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Cover of Org. Proc. Res. Dev.
Graphical abstract for Sustainable Flow Synthesis of a Versatile Cyclopentenone Building BlockGraphical abstract unavailable

Journal article

Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Baumann, M.; Baxendale, I. R.; Filipponi, P.; Hu, T.

Org. Proc. Res. Dev. · 2017 · 21 · 2052–2059

A flow based multistep processing sequence to reliably provide the delivery of a highly functional cyclopentenone is described. The exemplification of employing solid dosing of reagents and in-line aqueous extraction has enabled an integrated workflow in a hi…

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Cover of Tetrahedron
Graphical abstract for α,β-Unsaturated Ketones via Copper(II) Bromide Mediated OxidationGraphical abstract unavailable

Journal article

α,β-Unsaturated Ketones via Copper(II) Bromide Mediated Oxidation

Sharley, J. S.; Pérez, A. M. C.; Ferri, E. E.; Miranda, A. F.; Baxendale, I. R.

Tetrahedron · 2016 · 72 · 2947–2954

A protocol for effecting a rapid Saegusa-type oxidation of enol acetates is reported. This new method relies on the in-situ elimination of an α-bromo intermediate to generate α,β-unsaturated ketones using copper(II) bromide. The methodology developed was appl…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidantGraphical abstract unavailable

Journal article

Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Mallia, C. J.; Burton, P. M.; Smith, A. M. R.; Walter, G. C.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2016 · 12 · 1598–1607

A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has be…

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