Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.

201 publications found

Cover of Ind. & Eng. Chem. Res.
Graphical abstract for A multiple microcapillary reactor for organic synthesisGraphical abstract unavailable

Journal article

A multiple microcapillary reactor for organic synthesis

Hornung, C. H.; Hallmark, B.; Baumann, M.; Baxendale, I. R.; Ley, S. V.; Hester, P.; Clayton, P.; Mackley, M. R.

Ind. & Eng. Chem. Res. · 2010 · 49 · 4576–4582

This paper presents process characteristics and proof of concept reactions for a newly developed microreactor system, termed the Cambridge Disc Microreactor (CDM), using plastic microcapillary flow discs (MFDs). These flat reactor discs were constructed from …

Open DOIPDF
Cover of Adv. Synth. Catal.
Graphical abstract for A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer HydrogenationGraphical abstract unavailable

Journal article

A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation

Hornung, C. H.; Hallmark, B.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.

Adv. Synth. Catal. · 2010 · 352 · 1736–1745

Herein we describe the preparation of a novel continuous flow multi-channel microreactor in which the internal surface has been functionalised with a palladium coating, enabling its use in catalytic heterogeneous liquid-phase reactions. Simple chemical depos…

Open DOIPDF
Cover of Synlett
Graphical abstract for Enzymatic Oxidative Cyclisation Reactions Leading to DibenzoazocanesGraphical abstract unavailable

Journal article

Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes

Tozzi, F.; Ley, S. V.; Kitching, M. O.; Baxendale, I. R.

Synlett · 2010 · (13) · 1919–1922

From simple N-isovanillyltyramine derivatives double oxidative biotransformations can be achieved using tyrosinase leading to the corresponding hydroxylated dibenzoazocanes.

Open DOIPDF
Cover of Org. Lett.
Graphical abstract for Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid ContactGraphical abstract unavailable

Journal article

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact

O’Brien, M.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2010 · 12 · 1596–1598

A flow-through chemistry apparatus has been developed which allows gases and liquids to contact via a semipermeable Teflon AF-2400 membrane. In this preliminary investigation, the concept was proven by application to the ozonolysis of a series of alkenes.

Open DOIPDF
Cover of Org. Lett.
Graphical abstract for KMnO4 Mediated Oxidation as a Continuous Flow ProcessGraphical abstract unavailable

Journal article

KMnO4 Mediated Oxidation as a Continuous Flow Process

Sedelmeier, J.; Ley, S. V.; Ian R. Baxendale, I. R.; Baumann, M.

Org. Lett. · 2010 · 12 · 3618–3621

An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notab…

Open DOIPDF
Cover of Chem. Eur. J.
Graphical abstract for Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-ones and their use in Heterocycle SynthesisGraphical abstract unavailable

Journal article

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-ones and their use in Heterocycle Synthesis

Baxendale, I. R.; Schou, S. C.; Sedelmeier, J.; Ley, S. V.

Chem. Eur. J. · 2010 · 16 · 89–94

Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yneones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configu…

Open DOIPDF
Cover of Org. Biomol. Chem.
Graphical abstract for Preparation of arylsulfonyl chlorides by chlorosulfonylation of in-situ generated diazonium salts using a continuous flow reactorGraphical abstract unavailable

Journal article

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in-situ generated diazonium salts using a continuous flow reactor

Laia Malet-Sanz, L.; Madrzak, J.; Ley, S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 5324–5332

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labo…

Open DOIPDF
Cover of Org. Process Res. Dev.
Graphical abstract for ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical ProcessingGraphical abstract unavailable

Journal article

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode J. G.; Gaunt N. L.

Org. Process Res. Dev. · 2010 · 14 · 393–402

A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit …

Open DOIPDF
Cover of Synlett
Graphical abstract for Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow ReactorGraphical abstract unavailable

Journal article

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow Reactor

Baumann, M; Baxendale, I. R.; Ley, S. V.

Synlett · 2010 · (5) · 749–752

The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the …

Open DOIPDF
Cover of Heterocycles
Graphical abstract for Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow ReactorGraphical abstract unavailable

Journal article

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.

Heterocycles · 2010 · 82 · 1297–1316

We expand upon recent results concerning dipolar cycloaddition reactions of unstabilized azomethine ylids with nitro alkenes to generate 3-nitropyrrolidines via a flow chemistry sequence. This new work describes the development of a three-component coupling r…

Open DOIPDF
Cover of Org. Biomol. Chem.
Graphical abstract for The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I InhibitorsGraphical abstract unavailable

Journal article

The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Venturoni, F.; Nikbin, N.; Ley S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1798–1806

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particula…

Open DOIPDF
Cover of Org. Biomol. Chem.
Graphical abstract for The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using MicroreactorsGraphical abstract unavailable

Journal article

The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using Microreactors

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1588–1595

The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA pro…

Open DOIPDF