Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.

201 publications found

Cover of Org. Lett.
Graphical abstract for Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow ReactorGraphical abstract unavailable

Journal article

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Martin, L. J.; Marzinzik, A. L.; Ley, S. V.; Baxendale, I. R.

Org. Lett. · 2011 · 13 · 320–323

A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases…

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Cover of Synlett
Graphical abstract for Syngas Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of StyrenesGraphical abstract unavailable

Journal article

Syngas Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Kasinathan, S.; Bourne,S. L.; Tolstoy, P.; Koos, P.; O'Brien, M.; Bates, R. W.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (18) · 2648–2651

We report a continuous flow, rhodium-catalysed hydroformylation of various styrenes using a tube-in-tube gas-liquid reactor. The flow process afforded selectively branched aryl aldehydes in good yields.

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Cover of ACS Comb. Sci.
Graphical abstract for Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch MethodsGraphical abstract unavailable

Journal article

Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.

ACS Comb. Sci. · 2011 · 13 · 405–413

A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisubstituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structur…

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Cover of Org. Biomol. Chem.
Graphical abstract for Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentrationGraphical abstract unavailable

Journal article

Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Koos, P.; Gross, U.; Polyzos, A.; O'Brien, M.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2011 · 9 · 6903–6908

We report on the development of a continuous flow process for the palladium catalysed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of c…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactorsGraphical abstract unavailable

Journal article

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Roper, K. A.; Lange, H.; Polyzos, A.; Berry, M. B.; Baxendale, I. R.; Ley, S. V.

Beilstein J. Org. Chem. · 2011 · 7 · 1648–1655

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line pu…

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Cover of Angew. Chem. Int. Ed.
Graphical abstract for The Continuous Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas-Permeable Membrane ReactorGraphical abstract unavailable

Journal article

The Continuous Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas-Permeable Membrane Reactor

Polyzos A.; O'Brien M.; Petersen T. P.; Baxendale I. R.; Ley S. V.

Angew. Chem. Int. Ed. · 2011 · 49 · 1190–1193

Keep it simple: A gas-liquid flow reactor has been developed based on a gas permeable tube-in-tube configuration which effectively delivers gas to a liquid substrate stream in a safe, continuous fashion. A series of carboxylic acids were prepared from the rea…

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Cover of Synlett
Graphical abstract for The Continuous-Flow Synthesis of Styrenes using Ethylene in a Palladium Catalysed Heck Cross-Coupling ReactionGraphical abstract unavailable

Journal article

The Continuous-Flow Synthesis of Styrenes using Ethylene in a Palladium Catalysed Heck Cross-Coupling Reaction

Bourne, S. L.; Koos, P.; O'Brien,M.; Martin,B.; Schenkel, B.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (18) · 2643–2647

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

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Cover of Mol. Diversity
Graphical abstract for The Flow Synthesis of Heterocycles for Natural Product and Medicinal Chemistry ApplicationsGraphical abstract unavailable

Journal article

The Flow Synthesis of Heterocycles for Natural Product and Medicinal Chemistry Applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.

Mol. Diversity · 2011 · 15 · 615–630

This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we d…

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Cover of Chemica Oggi, Chemistry Today
Graphical abstract for The Lab of the Future: The Importance of Remote Monitoring and ControlGraphical abstract unavailable

Journal article

The Lab of the Future: The Importance of Remote Monitoring and Control

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Chemica Oggi, Chemistry Today · 2011 · 29(1) · 28–32

Chemical laboratories and the equipment within them have changed very little over the last two centuries. However, the introduction of enabling technologies and their impact on current working practices is starting to redefine the laboratory environment. In t…

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Cover of Chem. Euro. J.
Graphical abstract for A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid ReceptorGraphical abstract unavailable

Journal article

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2010 · 14 · 12342–12348

This article describes the design, optimisation and development of a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, a potent δ-opioid receptor agonist developed by AstraZeneca. The process employs a sequence of …

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Cover of Synlett
Graphical abstract for A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonistGraphical abstract unavailable

Journal article

A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Synlett · 2010 · (4) · 505–508

This article describes the continuous flow synthesis of ­6-methoxy-8-(4-methyl-1,4-diazepan-1-yl)-N-(4-morpholinophen-yl)-4-oxo-1,4-dihydroquinoline-2-carboxamide, a potent 5HT1B antagonist developed by AstraZeneca.

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Cover of Chem. Commun.
Graphical abstract for A flow-based synthesis of Imatinib: the API of GleevecGraphical abstract unavailable

Journal article

A flow-based synthesis of Imatinib: the API of Gleevec

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Chem. Commun. · 2010 · 46 · 2450–2452

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation.…

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