Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.

201 publications found

Cover of Synthesis
Graphical abstract for A Base-catalysed One-pot Three-component Coupling Reaction Leading to Nitrosubstituted PyrrolesGraphical abstract unavailable

Journal article

A Base-catalysed One-pot Three-component Coupling Reaction Leading to Nitrosubstituted Pyrroles

Baxendale, I. R.; Buckle, C. D.; Ley,S. V.; Tamborini, L.

Synthesis · 2009 · (9) · 1485–1493

Tosyl isocyanide and ethyl chloroformate react with nitrostyrenes to afford nitro-substituted pyrroles in good yield when a catch-and-release protocol was employed as a purification strategy.

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Cover of Tetrahedron Lett.
Graphical abstract for A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangementGraphical abstract unavailable

Journal article

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement

Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.

Tetrahedron Lett. · 2009 · 50 · 3287–3289

We report on the use of commercially available chemical microreactors to effect the Hofmann rearrangement of aromatic amides to the corresponding carbamates.

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Cover of Green Chem.
Graphical abstract for An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow processGraphical abstract unavailable

Journal article

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.

Green Chem. · 2009 · 11 · 683–685

We report the efficient reduction of a selection of ketones to the corresponding secondary alcohols using only catalytic amounts of LiOtBu in iPrOH facilitated by using a continuous flow reactor.

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Cover of Beilstein J. Org. Chem.
Graphical abstract for Continuous flow based catch and release protocol for the synthesis of a-KetoestersGraphical abstract unavailable

Journal article

Continuous flow based catch and release protocol for the synthesis of a-Ketoesters

Palmieri, A.; Ley, S. V.; Polyzos, A.; Ladlow, M.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2009 · 5(23) · 1–17

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of á-ketoesters is reported.

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Cover of Tetrahedron
Graphical abstract for Development of Fluorination Methods using Continuous-Flow MicroreactorsGraphical abstract unavailable

Journal article

Development of Fluorination Methods using Continuous-Flow Microreactors

Baumann, M.; Baxendale, I. R.; Martin, L. J.; Ley, S. V.

Tetrahedron · 2009 · 65 · 6611–6625

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert's reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was g…

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Cover of Angew. Chem. Int. Ed.
Graphical abstract for Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and TriazolesGraphical abstract unavailable

Journal article

Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Baxendale, I. R.; Ley, S. V.; Mansfield, A. C.; Smith, C. D.

Angew. Chem. Int. Ed. · 2009 · 48 · 4017–4021

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed …

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Cover of Beilstein J. Org. Chem.
Graphical abstract for New Tools for Molecule Makers: Emerging Technologies.Graphical abstract unavailable

Journal article

New Tools for Molecule Makers: Emerging Technologies.

Ley, S. V.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2009 · NA · 65–85

If one reflects for a moment about the current practices used by a skilled synthesis chemist, we must be impressed by the sheer complexity of what can be achieved. Moreover, the impact on society is staggering, given the array of healing drugs, compounds th…

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Cover of Eur. J. Org. Chem.
Graphical abstract for Pd-EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-substituted Acetylenes via Microwave Assisted Sonogashira type ReactionsGraphical abstract unavailable

Journal article

Pd-EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-substituted Acetylenes via Microwave Assisted Sonogashira type Reactions

Sedelmeier, J.; Ley, S. V.; Lange, H.; Baxendale, I. R.

Eur. J. Org. Chem. · 2009 · (26) · 4412–4420

We report a rapid microwave-assisted Sonogashira cross-coupling of aryl iodides and bromides with terminal alkynes using Pd-EnCatTM TPP30. Both electron-rich and electron-deficient aryl halides reacted smoothly with a broad variety of terminal alkynes in MeCN…

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Cover of Org. Biomol. Chem.
Graphical abstract for Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal TartratesGraphical abstract unavailable

Journal article

Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal Tartrates

Carter, C. F.; Baxendale, I. R.; O’Brien, M.; Pavey, J. B. J.; Ley, S. V.

Org. Biomol. Chem. · 2009 · 7 · 4594–4597

The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocols.

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Cover of J. Comb. Chem.
Graphical abstract for A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.Graphical abstract unavailable

Journal article

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Baxendale, I. R.; Smith, C. D.; Voica, F.; Tamborini, L.; Ley, S. V.

J. Comb. Chem. · 2008 · 10 · 851–857

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent colu…

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Cover of Org. Biomol. Chem.
Graphical abstract for A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow ProcessGraphical abstract unavailable

Journal article

A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.; Tierney, J. P.

Org. Biomol. Chem. · 2008 · 6 · 1577–1586

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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Cover of Synthesis
Graphical abstract for A New Focused Microwave Approach to Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-component Coupling ProcessGraphical abstract unavailable

Journal article

A New Focused Microwave Approach to Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-component Coupling Process

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Synthesis · 2008 · (11) · 1688–1702

A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their form…

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