Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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201 publications found

Cover of Chem. Sci.
Graphical abstract for A Breakthrough Method for the Accurate Addition of Reagents in Multi-step Segmented Flow ProcessingGraphical abstract unavailable

Journal article

A Breakthrough Method for the Accurate Addition of Reagents in Multi-step Segmented Flow Processing

Lange, H.; Carter, C. F.; Hopkin, M. D.; Burke, A.; Goode, J. G; Baxendale, I. R.; Ley S. V.

Chem. Sci. · 2011 · 2 · 765–769

In order to use segmented chemical flow processing in more complex reaction sequences, a method has been developed to precisely control the addition of reagent streams during multi-step operations. Using in-line infra-red monitoring with a new LabVIEW softwar…

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Cover of Org. Biomol. Chem.
Graphical abstract for A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazolesGraphical abstract unavailable

Journal article

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Smith, C. J.; Nikbin, N.; Ley, S. V.; Lange H.; Baxendale, I. R.

Org. Biomol. Chem. · 2011 · 9 · 1938–1947

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool…

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Cover of Org. Lett.
Graphical abstract for A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low TemperaturesGraphical abstract unavailable

Journal article

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Browne, D. L.; Baumann, M.; Harji, B. H.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2011 · 13 · 3312–3315

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium…

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Cover of Synlett
Graphical abstract for An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl SiphonazoleGraphical abstract unavailable

Journal article

An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl Siphonazole

Baumann, M.; Baxendale, I. R.; Brasholz, M.; Hayward, J. J.; Ley S. V.; Nikbin, N.

Synlett · 2011 · (10) · 1375–1380

The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purificatio…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticalsGraphical abstract unavailable

Journal article

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.

Beilstein J. Org. Chem. · 2011 · 7 · 442–495

This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have concentrated only on those drugs contain…

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Cover of Org. Process Res. Dev.
Graphical abstract for Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell ReactorGraphical abstract unavailable

Journal article

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

Browne, D. L.; Deadman, B. J.; Ashe, R.; Baxendale, I. R.; Ley, S. V.

Org. Process Res. Dev. · 2011 · 15 · 693–697

A general method for the continuous processing of suspensions and particulates is reported. A commercially available agitating cell reactor which uses a transverse mixing motion to maintain solids in suspension has been successfully applied to a salt-forming …

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Cover of Chem. Eur. J.
Graphical abstract for Diastereoselective Chain Elongation Reactions Using Microreactors for Application in Complex Molecule AssemblyGraphical abstract unavailable

Journal article

Diastereoselective Chain Elongation Reactions Using Microreactors for Application in Complex Molecule Assembly

Carter, C. F.; Lange, H.; Daiki Sakai, D.; Baxendale, I. R.; Ley, S. V.

Chem. Eur. J. · 2011 · 17 · 3398–3405

Diastereoselective chain-elongation reactions are important transformations for the assembly of complex molecular structures, such as those present in polyketide natural products. Here we report new methods for performing crotylation reactions and homoproparg…

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Cover of Org. Biomol. Chem.
Graphical abstract for Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagentGraphical abstract unavailable

Journal article

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Smith, C. J.; Nikbin, N.; Smith, C. D.; Ley, S. V.; Baxendale, I.R.

Org. Biomol. Chem. · 2011 · 9 · 1927–1937

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new …

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Cover of Chem. Sci.
Graphical abstract for Hydrogenation in Flow: Homogeneous and Heterogeneous Catalysis Using Teflon AF-2400 to Effect Gas-Liquid Contact at Elevated PressureGraphical abstract unavailable

Journal article

Hydrogenation in Flow: Homogeneous and Heterogeneous Catalysis Using Teflon AF-2400 to Effect Gas-Liquid Contact at Elevated Pressure

O'Brien, M.; Taylor, N.; Polyzos, A.; Baxendale, I. R.; Ley, S. V.

Chem. Sci. · 2011 · 2 · 1250–1257

A Tube-in-Tube reactor/injector has been developed, based on a gas-permeable Teflon AF-2400 membrane, which allows both heterogeneous and homogeneous catalytic hydrogenation reactions to be efficiently carried out at elevated pressure in flow, thereby increas…

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Cover of Org. Biomol. Chem.
Graphical abstract for Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analoguesGraphical abstract unavailable

Journal article

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues

Hodgkinson, J.; Galloway, W.; Saraf, S.; Baxendale, I.R.; Ley, S. V.; Ladlow, M.; Welch, M.; Spring, D.

Org. Biomol. Chem. · 2011 · 9 · 57–61

Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.

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Cover of Synlett
Graphical abstract for Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride MonolithGraphical abstract unavailable

Journal article

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Lange, H.; Capener, M. J.; Jones, A. X.; Smith, C. J.; Nikbin, N.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (6) · 869–873

A supported version of N-(tert-butyl)phenylsulfinimidoyl chloride on a monolithic material is described, which can be incorporated into a flow chemical processing arrangement to oxidise a variety of substrates in both stoichiometric and catalytic processes to…

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Cover of Tetrahedron
Graphical abstract for Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazinesGraphical abstract unavailable

Journal article

Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines

Browne, D. L.; Baxendale, I. R.; Ley, S. V.

Tetrahedron · 2011 · 67 · 10296–10303

A key intermediate for the synthesis of hydrazines via a mild, metal free reduction of diazonium salts has been isolated and characterized by X-ray analysis. The presence of this intermediate is general, as demonstrated by the preparation of a number of analo…

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