Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Synthesis
Graphical abstract for Flow Assisted Scale-up of C2-symmetric Chiral PyBox-Ligands

Journal article

Flow Assisted Scale-up of C2-symmetric Chiral PyBox-Ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.

Synthesis · 2012 · (4) · 635–647

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for im…

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Cover of Aust. J. Chem.
Graphical abstract for Flow Microwave Technology and Microreactors in Synthesis

Journal article

Flow Microwave Technology and Microreactors in Synthesis

Baxendale, I. R.; Hornung, C.; Ley, S. V.; Munõz Molina, J. de M.; Wikstrom, A.

Aust. J. Chem. · 2012 · 66 · 131–144

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A bespoke microwave reactor with a glass containment cell has been developed for performing continuous flow reactions under microwave heating. The prototype unit has been evaluated using a series of standard organic chemical transformations enabling scale-up …

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Graphical abstract for The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

Book chapter

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

Myers, R. M.; Roper, K. A.; Baxendale, I. R.; Ley, S. V.

Modern Tools for the Synthesis of Complex Bioactive Molecules · 2012 · Chapter 11 · 359–394

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsImmobilised reagents and scavengers

Underpinning a healthy drug discovery and development programme is the ability to prepare large numbers of structurally diverse molecules. Developing innovative practical chemical techniques to achieve this goal has therefore become essential. Indeed, the inc…

Cover of ChemSusChem
Graphical abstract for The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact.

Journal article

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact.

Petersen, T. P.; Polyzos, A.; O'Brien, M.; Ulven, T.; Baxendale, I. R.; Ley, S. V.

ChemSusChem · 2012 · 5 · 274–277

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

The gas is always greener: A continuous flow Glaser-Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liqu…

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Cover of Chem. Sci.
Graphical abstract for A Breakthrough Method for the Accurate Addition of Reagents in Multi-step Segmented Flow Processing

Journal article

A Breakthrough Method for the Accurate Addition of Reagents in Multi-step Segmented Flow Processing

Lange, H.; Carter, C. F.; Hopkin, M. D.; Burke, A.; Goode, J. G; Baxendale, I. R.; Ley S. V.

Chem. Sci. · 2011 · 2 · 765–769

Flow chemistry and reaction engineering

In order to use segmented chemical flow processing in more complex reaction sequences, a method has been developed to precisely control the addition of reagent streams during multi-step operations. Using in-line infra-red monitoring with a new LabVIEW softwar…

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Cover of Org. Lett.
Graphical abstract for A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Journal article

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Browne, D. L.; Baumann, M.; Harji, B. H.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2011 · 13 · 3312–3315

Route design and process chemistryFlow chemistry and reaction engineering

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium…

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Cover of Synlett
Graphical abstract for An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl Siphonazole

Journal article

An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl Siphonazole

Baumann, M.; Baxendale, I. R.; Brasholz, M.; Hayward, J. J.; Ley S. V.; Nikbin, N.

Synlett · 2011 · (10) · 1375–1380

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purificatio…

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Cover of Org. Process Res. Dev.
Graphical abstract for Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

Journal article

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

Browne, D. L.; Deadman, B. J.; Ashe, R.; Baxendale, I. R.; Ley, S. V.

Org. Process Res. Dev. · 2011 · 15 · 693–697

Flow chemistry and reaction engineering

A general method for the continuous processing of suspensions and particulates is reported. A commercially available agitating cell reactor which uses a transverse mixing motion to maintain solids in suspension has been successfully applied to a salt-forming …

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Cover of Chem. Eur. J.
Graphical abstract for Diastereoselective Chain Elongation Reactions Using Microreactors for Application in Complex Molecule Assembly

Journal article

Diastereoselective Chain Elongation Reactions Using Microreactors for Application in Complex Molecule Assembly

Carter, C. F.; Lange, H.; Daiki Sakai, D.; Baxendale, I. R.; Ley, S. V.

Chem. Eur. J. · 2011 · 17 · 3398–3405

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

Diastereoselective chain-elongation reactions are important transformations for the assembly of complex molecular structures, such as those present in polyketide natural products. Here we report new methods for performing crotylation reactions and homoproparg…

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Cover of Org. Biomol. Chem.
Graphical abstract for Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Journal article

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Smith, C. J.; Nikbin, N.; Smith, C. D.; Ley, S. V.; Baxendale, I.R.

Org. Biomol. Chem. · 2011 · 9 · 1927–1937

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsHazardous and reactive intermediates

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new …

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Cover of Chem. Sci.
Graphical abstract for Hydrogenation in Flow: Homogeneous and Heterogeneous Catalysis Using Teflon AF-2400 to Effect Gas-Liquid Contact at Elevated Pressure

Journal article

Hydrogenation in Flow: Homogeneous and Heterogeneous Catalysis Using Teflon AF-2400 to Effect Gas-Liquid Contact at Elevated Pressure

O'Brien, M.; Taylor, N.; Polyzos, A.; Baxendale, I. R.; Ley, S. V.

Chem. Sci. · 2011 · 2 · 1250–1257

Flow chemistry and reaction engineeringHazardous and reactive intermediates

A Tube-in-Tube reactor/injector has been developed, based on a gas-permeable Teflon AF-2400 membrane, which allows both heterogeneous and homogeneous catalytic hydrogenation reactions to be efficiently carried out at elevated pressure in flow, thereby increas…

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Cover of Synlett
Graphical abstract for Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Journal article

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Lange, H.; Capener, M. J.; Jones, A. X.; Smith, C. J.; Nikbin, N.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (6) · 869–873

Route design and process chemistryFlow chemistry and reaction engineering

A supported version of N-(tert-butyl)phenylsulfinimidoyl chloride on a monolithic material is described, which can be incorporated into a flow chemical processing arrangement to oxidise a variety of substrates in both stoichiometric and catalytic processes to…

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