Research record
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201 publications found
Graphical abstract unavailableJournal article
SynLett · 2016 · 27 · 159–163
Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-substitut…
Graphical abstract unavailableJournal article
React. Chem. Eng. · 2016 · 1 · 147–150
A new enabling technology for performing photochemical reactions in a continuous fashion is presented. This photo-reactor is compatible with existing flow systems and can be furthermore linked to a photo-spectrometer in order to allow for real time analysis o…
Graphical abstract unavailableJournal article
Org. Process Res. Dev. · 2016 · 20 · 371–375
In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an…
Graphical abstract unavailableJournal article
Tetrahedron · 2016 · 72 · 1645–1652
The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first ro…
Graphical abstract unavailableJournal article
J. Org. Chem. · 2016 · 81 · 11898–11908
A robust approach allowing for the efficient trifluoroacetylation of a series of highly substituted pyrrolidines in a diastereoselective manner is reported. The transformation is based on a Dakin–West reaction of advanced pyrrolidine 2-carboxylic acid derivat…
Graphical abstract unavailableJournal article
Molecules · 2016 · 21 · 918–941
The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including sev…
Graphical abstract unavailableJournal article
Beilstein J. Org. Chem. · 2016 · 12 · 1503–1511
The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acet…
Graphical abstract unavailableJournal article
React. Chem. Eng. · 2016 · 1 · 96–100
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. Th…
Graphical abstract unavailableJournal article
Euro. J. Org. Chem. · 2016 · 11 · 2000–2012
A continuous flow process delivering key building-blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor has emerged as a pivotal technology in both synthetic and isolation phases enabling the processing of slurries and s…
Graphical abstract unavailableJournal article
Org. Process Res. Dev. · 2016 · 20 · 327–360
This review will highlight the potential benefits that can be leveraged by using flow chemistry to allow gases to be used in research in a safer and more efficient way. An overview of the different approaches used to introduce gases into flow reactors is pres…
Graphical abstract unavailableJournal article
Org. Biomol. Chem. · 2015 · 13 · 1768–1777
An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor. The monolithic construct has been used for several redox reductions demonstrati…
Graphical abstract unavailableJournal article
Chem. Eng. Technol. · 2015 · 38 · 1713–1716
The search for novel chemical architectures displaying improved biological properties is a never-ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occu…
