Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Org. Process Res. Dev.
Graphical abstract for Controlled Flow Precipitation as a Valuable Tool for Synthesis

Journal article

Controlled Flow Precipitation as a Valuable Tool for Synthesis

Filipponi, P.; Gioiello, A.; Baxendale, I. R.

Org. Process Res. Dev. · 2016 · 20 · 371–375

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an…

Open DOIPDF
Cover of Molecules
Graphical abstract for Exploring Flow Procedures for Diazonium Formation

Journal article

Exploring Flow Procedures for Diazonium Formation

Hu, T.; Baxendale, I. R.; Baumann, M.

Molecules · 2016 · 21 · 918–941

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including sev…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Journal article

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Mallia, C. J.; Walter, G. C.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2016 · 12 · 1503–1511

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acet…

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Cover of React. Chem. Eng.
Graphical abstract for Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Journal article

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Holmes, N.; Akien, G. R.; Savage, R. J. D.; Stanetty, C.; Baxendale, I. R.; Blacker, A. J.; Taylor, B. A.; Woodward, R. L.; Meadows, R. E.; Bourne, R. A.

React. Chem. Eng. · 2016 · 1 · 96–100

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analytics

An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. Th…

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Cover of Euro. J. Org. Chem.
Graphical abstract for The Generation of a Library of Bromodomain Containing Protein Modulators Expedited by Continuous Flow Synthesis

Journal article

The Generation of a Library of Bromodomain Containing Protein Modulators Expedited by Continuous Flow Synthesis

Filipponi, P.; Baxendale, I. R.

Euro. J. Org. Chem. · 2016 · 11 · 2000–2012

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A continuous flow process delivering key building-blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor has emerged as a pivotal technology in both synthetic and isolation phases enabling the processing of slurries and s…

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Cover of Org. Process Res. Dev.
Graphical abstract for The Use of Gases in Flow Synthesis

Journal article

The Use of Gases in Flow Synthesis

Mallia, C. J.; Baxendale, I. R.

Org. Process Res. Dev. · 2016 · 20 · 327–360

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

This review will highlight the potential benefits that can be leveraged by using flow chemistry to allow gases to be used in research in a safer and more efficient way. An overview of the different approaches used to introduce gases into flow reactors is pres…

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Cover of Org. Biomol. Chem.
Graphical abstract for A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Journal article

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Rojo, M. V.; Guetzoyan, L.; Baxendale, I. R.

Org. Biomol. Chem. · 2015 · 13 · 1768–1777

Flow chemistry and reaction engineeringImmobilised reagents and scavengers

An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor. The monolithic construct has been used for several redox reductions demonstrati…

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Cover of Chem. Eng. Technol.
Graphical abstract for A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

Journal article

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

Baxendale, I. R.

Chem. Eng. Technol. · 2015 · 38 · 1713–1716

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The search for novel chemical architectures displaying improved biological properties is a never-ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occu…

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Cover of Chem. Eng. Tech.
Graphical abstract for Back Pressure Regulation of Slurry Forming Reactions in Continuous Flow

Journal article

Back Pressure Regulation of Slurry Forming Reactions in Continuous Flow

Deadman, B. J.; Ley, S. V.; Browne, D. L.; Baxendale, I. R.

Chem. Eng. Tech. · 2015 · 38 · 259–264

Flow chemistry and reaction engineering

The handling of solid components in flow chemical processes is still a significant challenge. Current devices for regulating back pressure in laboratory-scale flow chemistry experiments are vulnerable to blockage by solid particulates. A simple device is pres…

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Cover of J. Org. Chem.
Graphical abstract for Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

Journal article

Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

Baumann, M.; Baxendale, I. R.

J. Org. Chem. · 2015 · 80 · 10806–10816

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

An efficient reaction cascade delivering a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieties is presented. This sequence exploits the in situ transformation of propargylic alcohols into transient allenes by means of a strategi…

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Cover of Org. Biomol. Chem.
Graphical abstract for Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

Journal article

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

Baumann, M.; Rodriguez Garcia, A. M.; Baxendale, I. R.

Org. Biomol. Chem. · 2015 · 13 · 4231–4239

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The efficient flow synthesis of important heterocyclic building blocks based on the 1,2,4-triazole and pyrrolo[1,2-c]pyrimidine scaffold has been achieved. Crucially, a telescoped continuous flow process was developed based on the reaction of N-formylglycin…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for The synthesis of active pharmaceutical ingredients (APIs)using continuous flow chemistry

Journal article

The synthesis of active pharmaceutical ingredients (APIs)using continuous flow chemistry

Baumann, M.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2015 · 11 · 1194–1219

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analytics

The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant …

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