Research record
Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.
201 publications found
Graphical abstract unavailableJournal article
Synlett · 2002 · (5) · 775–777
A polymer-supported hydrazine reagent has been applied to the conversion of a range of aldehydes to nitriles, providing a clean and efficient route to more diverse building blocks for combinatorial chemistry programmes.
Graphical abstract unavailableJournal article
J. Chem. Soc. Perkin Trans. 1 · 2002 · 16 · 1850–1857
Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques. A new polymer-supported transition metal isomerisati…
Graphical abstract unavailableJournal article
Synlett · 2002 · (3) · 516–518
A polymer-supported iridium catalyst has been prepared and used in the isomerisation of the double bonds in aryl allylic derivatives with excellent trans selectivity and without the need for conventional work-up procedures.
Graphical abstract unavailableJournal article
Synlett · 2002 · (10) · 1641–1644
Polymer-supported pig liver esterase was used for the resolution of meso-diesters. The enzyme can be recovered quantitatively from the reaction mixture by filtration and reused without significant loss of activity. Further transformation of the resulting enan…
Graphical abstract unavailableJournal article
Nat. Rev. Drug Discovery · 2002 · 1 · 573–586
The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of …
Graphical abstract unavailableJournal article
Chem. Rec. · 2002 · 2 · 377–388
This article is based on a lecture presented to the Chemical Society of Japan at Wasada University on March 27, 2002, by Professor Steven V. Ley. The lecture, “Organic Synthesis in a Changing World,” was a comprehensive account of the ongoing research efforts…
Graphical abstract unavailableJournal article
Farmaco · 2002 · 57 · 321–330
Since the early days of combinatorial chemistry solid-phase organic synthesis has been the method of choice for the production of large libraries. Solution-phase synthesis is again gaining importance especially for the synthesis of parallel arrays of smaller,…
Graphical abstract unavailableJournal article
J. Chem. Soc. Perkin Trans. 1 · 2002 · NA · 143–154
The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotin…
Graphical abstract unavailableJournal article
Comb. Chem. & High Throughput Screening · 2002 · 5 · 197–199
A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.
Graphical abstract unavailableJournal article
Angew. Chem. Int. Ed. · 2002 · 41 · 2194–2197
A sequence of polymer-supported reagents and scavengers was used to promote the synthetic transformations in the first total synthesis of (+)-plicamine (1), a member of the amaryllidaceae alkaloid family, starting from L-4-hydroxyphenylglycine.
Graphical abstract unavailableJournal article
Tetrahedron · 2002 · 58 · 6285–6304
In this report we describe in full the total synthesis of the amaryllidaceae alkaloid (+)-plicamine 1 including a model compound study. In both cases the compounds were prepared using solid-supported reagents and scavengers in multi-step sequences of reaction…
Graphical abstract unavailableJournal article
Synlett · 2001 · (9) · 1482–1484
Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques.
