Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

201 publications found

Cover of Innovations in Pharmaceutical Technology
Graphical abstract for Microwave-Enhanced Palladium-Catalysed Reactions

Journal article

Microwave-Enhanced Palladium-Catalysed Reactions

Baxendale, I. R.; Pitts, M. R.

Innovations in Pharmaceutical Technology · 2005 · 18 · 86–90

Route design and process chemistry

Microencapsulated palladium has been shown to be compatible with microwave heating, offering benefits such as increased yields, higher purities and simple work-up procedures, and permitting access to many previously unattainable molecular assemblies.

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Cover of Org. Biomol. Chem.
Graphical abstract for Non-Metal Catalysed Intramolecular Alkyne Cyclotrimerization Reactions Promoted by Focussed Microwave Heating in Batch and Flow Modes.

Journal article

Non-Metal Catalysed Intramolecular Alkyne Cyclotrimerization Reactions Promoted by Focussed Microwave Heating in Batch and Flow Modes.

Baxendale, I. R.; Ley, S. V.; Saaby, S.

Org. Biomol. Chem. · 2005 · 3 · 3365–3368

A number of oligomeric alkynes underwent [2 + 2 + 2] intramolecular trimerization to afford arenes under metal-free conditions using focussed microwave heating.

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Cover of Curr. Org. Chem.
Graphical abstract for Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Journal article

Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Baxendale, I. R.; Ley, I. R.

Curr. Org. Chem. · 2005 · 9 · 1521–1534

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase app…

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Cover of Ind. & Eng. Chem. Res.
Graphical abstract for Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Journal article

Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.

Ind. & Eng. Chem. Res. · 2005 · 44 · 8588–8592

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Two new naturally occurring amaryllidaceae alkaloids have been synthesized, using a divergent approach facilitated by the use of polymer-supported reagents and scavengers.

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Cover of Tetrahedron
Graphical abstract for The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Journal article

The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.; Martinelli, M.

Tetrahedron · 2005 · 61 · 5323–5349

Synthetic and heterocyclic chemistryRoute design and process chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydr…

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Cover of Org. Biomol. Chem.
Graphical abstract for Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Journal article

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Siu, J.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2004 · 2 · 160–167

Synthetic and heterocyclic chemistry

The development of enhanced conditions for Lewis acid catalysed Leimgruber–Batcho indole synthesis using microwave acceleration is described.

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Cover of Chem. Euro. J.
Graphical abstract for Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Journal article

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Storer, R. I.; Takemoto, T.; Jackson, P.S.; Brown, D. S.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2004 · 10 · 2529–2547

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-…

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Graphical abstract for Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Book chapter

Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Ley, S. V.; Baxendale, I. R.; Grice, P.

Chemical Probes in Biology (NATO Science series) · 2003 · Series Volume 129 · 235–244

Synthetic and heterocyclic chemistryRoute design and process chemistry

The synthesis of organic compounds, especially biologically active molecules, is a very complex task involving many important decision making steps. These decisions are especially important at the synthesis planning stage where issues of regio-, chemo- and st…

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Cover of Heterocyles
Graphical abstract for Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Journal article

Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Baxendale, I. R.; Davidson, T. D.; Ley, S. V.; Perni, R. H.

Heterocyles · 2003 · 60 · 2707–2715

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials…

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