Research record

Publications

Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.

201 publications found

Journal article

[3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith S. C.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1559–1561

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

Open DOI PDF

Journal article

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Chem. Commun. · 2006 · 24 · 2566–2568

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalys…

Open DOI PDF

Graphical abstract for A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Journal article

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Chem. Commun. · 2006 · NA · 4835–4837

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the m…

Open DOI PDF

Journal article

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Org. Lett. · 2006 · 8 · 5231–5234

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured …

Open DOI PDF

Graphical abstract for Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Journal article

Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Eur. J. Chem. · 2006 · 12 · 4407–4416

This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCatTM) under microwave irradiation. The methodology has been used in both batch mode for classic…

Open DOI PDF

Journal article

Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Baxendale, I. R.; Pitts, M. R.

Chimica Oggi, Chemistry Today · 2006 · 24 · 41–45

Microwave assisted chemistry is an increasingly important tool in the medicinal chemist’s quest to speed up drug development. With the development of commercial focussed-microwave reactors, reactions can be carried out safely and reproducibly at a useful labo…

PDF

Book chapter

Polymer-Supported Regents, Scavengers and Catch-and-Release Techniques for Chemical Synthesis

Ley, S. V.; Baxendale, I. R.; Myers, R. M.

Comprehensive Medicinal Chemistry II · 2006 · Volume 3, Drug Discovery Technologies · 791–839

Abstract not currently available.

Journal article

Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process.

Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Synlett · 2006 · (3) · 427–430

This article describes the first enantioselective total synthesis of 2-aryl-2,3-dihydro-3-benzofurancarboxyamide neolignan, grossamide (1) using a fully automated and scalable flow reactor.

Open DOI PDF

Book chapter

The Use of Polymer Supported Reagents and Scavengers in the Synthesis of Natural Products

Ley, S. V.; Baxendale, I. R.; Myers, R. M.

Combinatorial Synthesis of Natural Product-Based Libraries · 2006 · Chapter 6 · 131–163

Abstract not currently available.

Graphical abstract for A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Journal article

A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Siu, J.; Baxendale, I. R.; Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2005 · 3 · 3140–3160

In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic ‘catch and release’ methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-b…

Open DOI PDF

Book chapter

Evolution or Revolution: The Challenge to the Modern Medicinal Chemist

Ley, S. V.; I.R. Baxendale, I. R.; Myers, R. M.

The Chemical Theatre of Biological Systems (Proceedings of the Beilstein-Institut Workshop, May 24th-28th 2004, Bozen) · 2005 · Chapter 1 · 1–31

Abstract not currently available.

Journal article

Formation of 4-Aminopyrimidines via the Trimerization of Nitriles using Focused Microwave Heating.

Baxendale, I. R.; Ley, S. V.

J. Comb. Chem. · 2005 · 7 · 483–489

A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantiti…

Open DOI PDF