Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Tetrahedron
Graphical abstract for Development of Fluorination Methods using Continuous-Flow Microreactors

Journal article

Development of Fluorination Methods using Continuous-Flow Microreactors

Baumann, M.; Baxendale, I. R.; Martin, L. J.; Ley, S. V.

Tetrahedron · 2009 · 65 · 6611–6625

Flow chemistry and reaction engineering

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert's reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was g…

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Cover of Angew. Chem. Int. Ed.
Graphical abstract for Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Journal article

Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Baxendale, I. R.; Ley, S. V.; Mansfield, A. C.; Smith, C. D.

Angew. Chem. Int. Ed. · 2009 · 48 · 4017–4021

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed …

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Cover of Org. Biomol. Chem.
Graphical abstract for Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal Tartrates

Journal article

Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal Tartrates

Carter, C. F.; Baxendale, I. R.; O’Brien, M.; Pavey, J. B. J.; Ley, S. V.

Org. Biomol. Chem. · 2009 · 7 · 4594–4597

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocols.

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Cover of J. Comb. Chem.
Graphical abstract for A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Journal article

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Baxendale, I. R.; Smith, C. D.; Voica, F.; Tamborini, L.; Ley, S. V.

J. Comb. Chem. · 2008 · 10 · 851–857

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent colu…

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Cover of Org. Biomol. Chem.
Graphical abstract for A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process

Journal article

A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.; Tierney, J. P.

Org. Biomol. Chem. · 2008 · 6 · 1577–1586

Flow chemistry and reaction engineeringHazardous and reactive intermediates

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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Cover of Org. Biomol. Chem.
Graphical abstract for Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions

Journal article

Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.

Org. Biomol. Chem. · 2008 · 6 · 1587–1593

Flow chemistry and reaction engineeringHazardous and reactive intermediates

The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs.

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Graphical abstract for Organic Chemistry in Microreactors; Heterogenous Reactions

Book chapter

Organic Chemistry in Microreactors; Heterogenous Reactions

Baxendale, I. R.; Hayward, J. J.; Lanners, S.; Ley, S. V.; Smith, C. D.

Microreactors in Organic Chemistry and Catalysis · 2008 · Chapter 4.2 · 84–121

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

Modern organic synthesis is undergoing a period of rapid change due to the many demands challenging it today. The need for greater speed in the discovery process requires high‑throughput methods and inevitably more advanced automation. However, safety factors…

Cover of Chimia
Graphical abstract for The Changing Face of Organic Synthesis

Journal article

The Changing Face of Organic Synthesis

Ley, S. V.; Baxendale, I. R.

Chimia · 2008 · 62 · 162–168

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors…

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Cover of Synlett
Graphical abstract for The Use of diethylaminosulfurtrifluoride (DAST) for Fluorination in a Continuous Flow Microreactor

Journal article

The Use of diethylaminosulfurtrifluoride (DAST) for Fluorination in a Continuous Flow Microreactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.

Synlett · 2008 · (14) · 2111–2114

Flow chemistry and reaction engineering

The convenient and safe use of diethylaminosulfur tri­fluoride as a fluorinating agent in a continuous-flow microreactor is described using an in-line purification method to obtain clean reaction products.

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Cover of Org. Proc. Res. Dev.
Graphical abstract for A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Journal article

A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Hornung, C. H.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.

Org. Proc. Res. Dev. · 2007 · 11 · 399–405

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

This paper reports proof of concept, development, and trials for a novel plastic microcapillary flow disc (MFD) reactor. The MFD was constructed from a flexible, plastic microcapillary film (MCF), comprising parallel capillary channels with diameters in the r…

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Cover of Combinatorial Chemistry & High Throughput Screening
Graphical abstract for Microwave Reactions under Continuous Flow Conditions.

Journal article

Microwave Reactions under Continuous Flow Conditions.

Baxendale, I. R.; Hayward, J. J.; Ley. S. V.

Combinatorial Chemistry & High Throughput Screening · 2007 · 10 · 802–836

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringPhotochemistry

Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered to…

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Cover of Org. Biomol. Chem.
Graphical abstract for Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Journal article

Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Smith, C. D.; Baxendale, I. R.; Tranmer, G. K.; Baumann, M.; Smith, S. C.; Russell A. Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1562–1568

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and…

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