Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Org. Lett.
Graphical abstract for Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact

Journal article

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact

O’Brien, M.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2010 · 12 · 1596–1598

Flow chemistry and reaction engineeringHazardous and reactive intermediates

A flow-through chemistry apparatus has been developed which allows gases and liquids to contact via a semipermeable Teflon AF-2400 membrane. In this preliminary investigation, the concept was proven by application to the ozonolysis of a series of alkenes.

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Cover of Org. Lett.
Graphical abstract for KMnO4 Mediated Oxidation as a Continuous Flow Process

Journal article

KMnO4 Mediated Oxidation as a Continuous Flow Process

Sedelmeier, J.; Ley, S. V.; Ian R. Baxendale, I. R.; Baumann, M.

Org. Lett. · 2010 · 12 · 3618–3621

Flow chemistry and reaction engineering

An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notab…

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Cover of Chem. Eur. J.
Graphical abstract for Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-ones and their use in Heterocycle Synthesis

Journal article

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-ones and their use in Heterocycle Synthesis

Baxendale, I. R.; Schou, S. C.; Sedelmeier, J.; Ley, S. V.

Chem. Eur. J. · 2010 · 16 · 89–94

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yneones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configu…

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Cover of Org. Biomol. Chem.
Graphical abstract for Preparation of arylsulfonyl chlorides by chlorosulfonylation of in-situ generated diazonium salts using a continuous flow reactor

Journal article

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in-situ generated diazonium salts using a continuous flow reactor

Laia Malet-Sanz, L.; Madrzak, J.; Ley, S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 5324–5332

Flow chemistry and reaction engineeringHazardous and reactive intermediates

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labo…

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Cover of Org. Process Res. Dev.
Graphical abstract for ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Journal article

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode J. G.; Gaunt N. L.

Org. Process Res. Dev. · 2010 · 14 · 393–402

Route design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit …

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Cover of Synlett
Graphical abstract for Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow Reactor

Journal article

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow Reactor

Baumann, M; Baxendale, I. R.; Ley, S. V.

Synlett · 2010 · (5) · 749–752

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the …

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Cover of Heterocycles
Graphical abstract for Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Journal article

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.

Heterocycles · 2010 · 82 · 1297–1316

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

We expand upon recent results concerning dipolar cycloaddition reactions of unstabilized azomethine ylids with nitro alkenes to generate 3-nitropyrrolidines via a flow chemistry sequence. This new work describes the development of a three-component coupling r…

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Cover of Org. Biomol. Chem.
Graphical abstract for The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Journal article

The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Venturoni, F.; Nikbin, N.; Ley S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1798–1806

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsHazardous and reactive intermediatesImmobilised reagents and scavengers

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particula…

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Cover of Org. Biomol. Chem.
Graphical abstract for The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using Microreactors

Journal article

The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using Microreactors

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1588–1595

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA pro…

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Cover of Tetrahedron Lett.
Graphical abstract for A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement

Journal article

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement

Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.

Tetrahedron Lett. · 2009 · 50 · 3287–3289

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

We report on the use of commercially available chemical microreactors to effect the Hofmann rearrangement of aromatic amides to the corresponding carbamates.

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Cover of Green Chem.
Graphical abstract for An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Journal article

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.

Green Chem. · 2009 · 11 · 683–685

Flow chemistry and reaction engineeringHazardous and reactive intermediates

We report the efficient reduction of a selection of ketones to the corresponding secondary alcohols using only catalytic amounts of LiOtBu in iPrOH facilitated by using a continuous flow reactor.

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Cover of Beilstein J. Org. Chem.
Graphical abstract for Continuous flow based catch and release protocol for the synthesis of a-Ketoesters

Journal article

Continuous flow based catch and release protocol for the synthesis of a-Ketoesters

Palmieri, A.; Ley, S. V.; Polyzos, A.; Ladlow, M.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2009 · 5(23) · 1–17

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of á-ketoesters is reported.

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