Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

53 publications found for Route design and process chemistry

Cover of Org. Lett.
Graphical abstract for A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Journal article

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Browne, D. L.; Baumann, M.; Harji, B. H.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2011 · 13 · 3312–3315

Route design and process chemistryFlow chemistry and reaction engineering

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium…

Open DOIPDF
Cover of Synlett
Graphical abstract for Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Journal article

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Lange, H.; Capener, M. J.; Jones, A. X.; Smith, C. J.; Nikbin, N.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (6) · 869–873

Route design and process chemistryFlow chemistry and reaction engineering

A supported version of N-(tert-butyl)phenylsulfinimidoyl chloride on a monolithic material is described, which can be incorporated into a flow chemical processing arrangement to oxidise a variety of substrates in both stoichiometric and catalytic processes to…

Open DOIPDF
Cover of Chem. Euro. J.
Graphical abstract for A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Journal article

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2010 · 14 · 12342–12348

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

This article describes the design, optimisation and development of a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, a potent δ-opioid receptor agonist developed by AstraZeneca. The process employs a sequence of …

Open DOIPDF
Cover of Org. Process Res. Dev.
Graphical abstract for ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Journal article

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode J. G.; Gaunt N. L.

Org. Process Res. Dev. · 2010 · 14 · 393–402

Route design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit …

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Cover of Org. Biomol. Chem.
Graphical abstract for The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Journal article

The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Venturoni, F.; Nikbin, N.; Ley S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1798–1806

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsHazardous and reactive intermediatesImmobilised reagents and scavengers

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particula…

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Cover of Green. Chem.
Graphical abstract for The application of focused microwave irradiation coupled with freeze drying to investigate the reaction of MgO and Al2O3 slurries in the formation of layered double hydroxides

Journal article

The application of focused microwave irradiation coupled with freeze drying to investigate the reaction of MgO and Al2O3 slurries in the formation of layered double hydroxides

Mitchell, S.; Baxendale, I. R.; Jones, W.

Green. Chem. · 2008 · 10 · 629–634

Route design and process chemistryPhotochemistry

Focused microwave irradiation (MI) and freeze drying (FD) techniques have been used to study the generation of layered double hydroxides prepared from MgO–Al2O3–H2O systems. Reactions were undertaken at temperatures of between 100 and 180 °C in order to study…

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Cover of Chimia
Graphical abstract for The Changing Face of Organic Synthesis

Journal article

The Changing Face of Organic Synthesis

Ley, S. V.; Baxendale, I. R.

Chimia · 2008 · 62 · 162–168

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors…

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Cover of Org. Proc. Res. Dev.
Graphical abstract for A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Journal article

A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Hornung, C. H.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.

Org. Proc. Res. Dev. · 2007 · 11 · 399–405

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

This paper reports proof of concept, development, and trials for a novel plastic microcapillary flow disc (MFD) reactor. The MFD was constructed from a flexible, plastic microcapillary film (MCF), comprising parallel capillary channels with diameters in the r…

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Cover of Org. Biomol. Chem.
Graphical abstract for Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Journal article

Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Smith, C. D.; Baxendale, I. R.; Tranmer, G. K.; Baumann, M.; Smith, S. C.; Russell A. Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1562–1568

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and…

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Cover of Eur. J. Chem.
Graphical abstract for Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Journal article

Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Eur. J. Chem. · 2006 · 12 · 4407–4416

Route design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCatTM) under microwave irradiation. The methodology has been used in both batch mode for classic…

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Cover of Chimica Oggi, Chemistry Today
Graphical abstract for Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Journal article

Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Baxendale, I. R.; Pitts, M. R.

Chimica Oggi, Chemistry Today · 2006 · 24 · 41–45

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Microwave assisted chemistry is an increasingly important tool in the medicinal chemist’s quest to speed up drug development. With the development of commercial focussed-microwave reactors, reactions can be carried out safely and reproducibly at a useful labo…

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Cover of Innovations in Pharmaceutical Technology
Graphical abstract for Microwave-Enhanced Palladium-Catalysed Reactions

Journal article

Microwave-Enhanced Palladium-Catalysed Reactions

Baxendale, I. R.; Pitts, M. R.

Innovations in Pharmaceutical Technology · 2005 · 18 · 86–90

Route design and process chemistry

Microencapsulated palladium has been shown to be compatible with microwave heating, offering benefits such as increased yields, higher purities and simple work-up procedures, and permitting access to many previously unattainable molecular assemblies.

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