Research record
Search the group’s publication record by scientific topic, author, journal, year or DOI. Journal covers, graphical abstracts and concise summaries make the underlying chemistry easier to discover.
201 publications found
Graphical abstract unavailableJournal article
Org. Biomol. Chem. · 2008 · 6 · 1587–1593
The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs.
Graphical abstract unavailableBook chapter
Microreactors in Organic Chemistry and Catalysis · 2008 · Chapter 4.2 · 84–121
Modern organic synthesis is undergoing a period of rapid change due to the many demands challenging it today. The need for greater speed in the discovery process requires high‑throughput methods and inevitably more advanced automation. However, safety factors…
Graphical abstract unavailableJournal article
Green. Chem. · 2008 · 10 · 629–634
Focused microwave irradiation (MI) and freeze drying (FD) techniques have been used to study the generation of layered double hydroxides prepared from MgO–Al2O3–H2O systems. Reactions were undertaken at temperatures of between 100 and 180 °C in order to study…
Graphical abstract unavailableJournal article
Chimia · 2008 · 62 · 162–168
The article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors…
Graphical abstract unavailableJournal article
Synlett · 2008 · (14) · 2111–2114
The convenient and safe use of diethylaminosulfur trifluoride as a fluorinating agent in a continuous-flow microreactor is described using an in-line purification method to obtain clean reaction products.
Graphical abstract unavailableJournal article
Org. Proc. Res. Dev. · 2007 · 11 · 399–405
This paper reports proof of concept, development, and trials for a novel plastic microcapillary flow disc (MFD) reactor. The MFD was constructed from a flexible, plastic microcapillary film (MCF), comprising parallel capillary channels with diameters in the r…
Graphical abstract unavailableJournal article
Org. Biomol. Chem. · 2007 · 5 · 2758–2761
A new approach to the synthesis of 5-amino-4-cyanopyrazoles has been developed, utilising a novel flow microwave device. These products are then converted by a batch mode microwave process to structurally more complex dimeric and ‘mixed’ pyrazolopyrimidine st…
Graphical abstract unavailableJournal article
Combinatorial Chemistry & High Throughput Screening · 2007 · 10 · 802–836
Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered to…
Graphical abstract unavailableBook chapter
In Drug Discovery & Development · 2007 · Chapter 2 · 51–91
The natural world inspires us all; from artist and philosopher to biologist and chemist alike. In our quest for new knowledge, the exquisite and varied architectures of natural products provide a rich pallet for discovery. Whether these are used to probe biol…
Graphical abstract unavailableJournal article
MedChemMed · 2007 · 2 · 768–788
The pharmaceutical industry is under increasing pressure on many fronts, from investors requiring larger returns to consumer groups and health authorities demanding cheaper and safer drugs. It is also feeling additional pressure from the infringement upon its…
Graphical abstract unavailableBook chapter
New Avenues to Efficient Chemical Synthesis: Emerging Technologies (Ernst Schering Foundation Symposium Proceedings 2006-3.) · 2007 · Chapter 9 · 151–187
The frequently overlooked benefits that considerably simplify and enrich our standard of living are most often hinged upon chemical synthesis. From the development of drugs in the ongoing fight against disease to the more aesthetic aspects of society with the…
Graphical abstract unavailableJournal article
Org. Biomol. Chem. · 2007 · 5 · 1562–1568
The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and…
