Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

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Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

54 publications found for Immobilised reagents and scavengers

Cover of Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series
Graphical abstract for Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Book chapter

Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Brocken, L.; Baxendale. I. R.

Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series · 2020 · Chapter 8 · 257–315

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

Although ionic polymerisations are a valuable methodology historically they are less widely used because they are considered capricious, requiring significantly more optimisation due to their sensitivity to the specific reaction and processing conditions. …

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Cover of Euro. J. Org. Chem.
Graphical abstract for A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

Journal article

A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

Mortzfeld, F. B.; Pietruszka, J.; Baxendale, I. R.

Euro. J. Org. Chem. · 2019 · X · 5424–5433

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product have been facilitated by the use of flow chemistry techniques and immobilised reagents. Us…

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Cover of Chem. Commun.
Graphical abstract for A solid-supported arylboronic acid catalyst for direct amidation

Journal article

A solid-supported arylboronic acid catalyst for direct amidation

Du, Y.; Barber, T.; Lim, S. E.; Baxendale, I. R.; Whiting, A.

Chem. Commun. · 2019 · 55 · 2916–2919

Flow chemistry and reaction engineeringImmobilised reagents and scavengers

A new catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid to derive a efficient heterogeneous direct amidation catalyst. The catalyst shows wide substrate applicability and higher levels of reactivity than the equivalent…

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Cover of Molecules
Graphical abstract for Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles

Journal article

Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles

Nicholls, A. J.; Batsanov, A. S.; Baxendale, I. R.

Molecules · 2019 · 24(22) · 4154–(1-19)

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

A simple protocol yielding ortho-substituted nitrosophenols from phenols is demonstrated, in the form of copper(II) bis(nitrosophenolato) complexes. The developed methodology was applied to a range of substrates, confirming the role of the copper in both the …

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Cover of Molbank
Graphical abstract for Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2- carboxylate

Journal article

Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2- carboxylate

Baumman, M.; Baxendale, I. R.

Molbank · 2017 · M951

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and…

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Cover of Org. Biomol. Chem.
Graphical abstract for A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Journal article

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

Rojo, M. V.; Guetzoyan, L.; Baxendale, I. R.

Org. Biomol. Chem. · 2015 · 13 · 1768–1777

Flow chemistry and reaction engineeringImmobilised reagents and scavengers

An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor. The monolithic construct has been used for several redox reductions demonstrati…

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Cover of Chem. Eur. J.
Graphical abstract for A Machine-Assisted Flow Synthesis of SR48692: a Probe for the Investigation of Neurotensin Receptor-1

Journal article

A Machine-Assisted Flow Synthesis of SR48692: a Probe for the Investigation of Neurotensin Receptor-1

Battilocchio, C.; Deadman, B. J.; Nikbin N.; Kitching, M. O.; Baxendale, I. R.; Ley, S. V.

Chem. Eur. J. · 2013 · 19 · 7917–7930

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported …

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Cover of J. Chem. Technol. Biotechnol.
Graphical abstract for The integration of flow reactors into synthetic organic chemistry

Journal article

The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.

J. Chem. Technol. Biotechnol. · 2013 · 88 · 519–552

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The material presented in this review is based upon discussions and interactions with members of the Department of Chemistry and Biochemistry within the University of Windsor, Ontario, Canada. This article explores the changing face of chemical synthesis with…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for The rapid generation of isothiocyanates in flow

Journal article

The rapid generation of isothiocyanates in flow

Baumann, M.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2013 · 9 · 1613–1619

Route design and process chemistryImmobilised reagents and scavengers

Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formatio…

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Graphical abstract for The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

Book chapter

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

Myers, R. M.; Roper, K. A.; Baxendale, I. R.; Ley, S. V.

Modern Tools for the Synthesis of Complex Bioactive Molecules · 2012 · Chapter 11 · 359–394

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsImmobilised reagents and scavengers

Underpinning a healthy drug discovery and development programme is the ability to prepare large numbers of structurally diverse molecules. Developing innovative practical chemical techniques to achieve this goal has therefore become essential. Indeed, the inc…

Cover of Synlett
Graphical abstract for An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl Siphonazole

Journal article

An Integrated Flow and Batch-based Approach for the Synthesis of O-Methyl Siphonazole

Baumann, M.; Baxendale, I. R.; Brasholz, M.; Hayward, J. J.; Ley S. V.; Nikbin, N.

Synlett · 2011 · (10) · 1375–1380

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The bisoxazole containing natural product O-methyl siphonazole was assembled using a suite of microreactors via a flow-based approach in concert with traditional batch methods. The use of a toolbox of solid-supported scavengers and reagents to aid purificatio…

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Cover of Org. Lett.
Graphical abstract for Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Journal article

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Martin, L. J.; Marzinzik, A. L.; Ley, S. V.; Baxendale, I. R.

Org. Lett. · 2011 · 13 · 320–323

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases…

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