Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the archive and use research tags to move between publications and the group’s scientific programme.

Clear
Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Tetrahedron
Graphical abstract for A Simple One-Pot Oxidation Protocol for the Synthesis of Dehydrohedione from Hedione

Journal article

A Simple One-Pot Oxidation Protocol for the Synthesis of Dehydrohedione from Hedione

Sharley, J. S.; Gambacorta, G.; Collado Pérezb, A. M.; Ferri, E. E.; Miranda, A. F.; Fernández, I. F.; Quesada, J. S.; Baxendale, I. R.

Tetrahedron · 2022 · 126 · 133068(1)–133068(11)

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

A new method of oxidising Hedione 1 to dehydrohedione 2, a highly valuable target in the flavour and fragrance industry, was developed based on α-chlorination-elimination. The spontaneous elimination of the α-chloro intermediate 5 in methanol was unprecedente…

Open DOIPDF
Cover of Org. Process Res. Dev.
Graphical abstract for Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone

Journal article

Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone

Gambacorta, G.; Baxendale, I. R.

Org. Process Res. Dev. · 2022 · 26 · 422–430

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

A continuous-flow preparation of 2-benzoxazolinone via the Hofmann rearrangement of salicylamide has been implemented employing trichloroisocyanuric acid as the stable and atom-economic chlorinating agent. The system was optimized to avoid solid accumulation …

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Journal article

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta, G.; Sharley, J. S.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2021 · 17 · 1181–1312

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the p…

Open DOIPDF
Cover of J. Org. Chem.
Graphical abstract for Synthesis of 7-Chloroquinoline Derivatives Using Mixed Lithium-Magnesium Reagents

Journal article

Synthesis of 7-Chloroquinoline Derivatives Using Mixed Lithium-Magnesium Reagents

Murie, V. E.; Nicolino, P. V.; dos Santos, T.; Gambacorta, G.; R. H. V. Nishimura, R. H. V., Perovani, I. S.; Furtado, L. C.; Costa-Lotufo, L. V.; de Oliveira, A. M.; Vessecchi, R.; Baxendale, I. R.; Clososki, G. C.

J. Org. Chem. · 2021 · 86 · 13402–13419

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

We have prepared a library of functionalized quinolines through the magnesiation of 7-chloroquinolines under mild conditions, employing both batch and continuous flow conditions. The preparation involved the generation of mixed lithium-magnesium intermediat…

Open DOIPDF
Cover of Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series
Graphical abstract for Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Book chapter

Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Brocken, L.; Baxendale. I. R.

Flow Chemistry: Integrated Approaches for Practical Applications - Green Chemistry Series · 2020 · Chapter 8 · 257–315

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

Although ionic polymerisations are a valuable methodology historically they are less widely used because they are considered capricious, requiring significantly more optimisation due to their sensitivity to the specific reaction and processing conditions. …

PDF
Cover of Flow Chemistry: Integrated Approaches for Practical Applications
Graphical abstract for Radical Polymerisation under Flow Conditions

Book chapter

Radical Polymerisation under Flow Conditions

Brocken, L.; Baxendale. I. R.

Flow Chemistry: Integrated Approaches for Practical Applications · 2020 · Chapter 7 · 217–256

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

Polymers are an important class of compounds used in many commercial products; for example, in the aerospace and automotive industries functioning as low weight construction parts and seals, through into the packaging of food and drink and even as aqueous s…

PDF
Cover of J. Org. Chem.
Graphical abstract for Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

Journal article

Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

Ruggeri, M.; Dombrowski, A. W.; Djuric, S. W.; Baxendale, I. R.

J. Org. Chem. · 2020 · 85 · 7276–7286

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A novel rearrangement sequence of 3-hydroxyazetidines via a Ritter initiated cascade provides highly substituted 2-oxazolines in high yields. The reaction conditions and substrate scope of the transformation have been studied demonstrating the generality of t…

Open DOIPDF
Cover of Euro. J. Org. Chem.
Graphical abstract for A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

Journal article

A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa

Mortzfeld, F. B.; Pietruszka, J.; Baxendale, I. R.

Euro. J. Org. Chem. · 2019 · X · 5424–5433

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product have been facilitated by the use of flow chemistry techniques and immobilised reagents. Us…

Open DOIPDF
Cover of Chem. Commun.
Graphical abstract for A solid-supported arylboronic acid catalyst for direct amidation

Journal article

A solid-supported arylboronic acid catalyst for direct amidation

Du, Y.; Barber, T.; Lim, S. E.; Baxendale, I. R.; Whiting, A.

Chem. Commun. · 2019 · 55 · 2916–2919

Flow chemistry and reaction engineeringImmobilised reagents and scavengers

A new catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid to derive a efficient heterogeneous direct amidation catalyst. The catalyst shows wide substrate applicability and higher levels of reactivity than the equivalent…

Open DOIPDF
Cover of Molecules
Graphical abstract for Flow Hydrodediazotization of Aromatic Heterocycles

Journal article

Flow Hydrodediazotization of Aromatic Heterocycles

Röder, L.; Nicholls, A. J.; Baxendale, I. R.

Molecules · 2019 · 24(10) · 1996–1996(18)

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was …

Open DOIPDF
Cover of ChemPhotoChem
Graphical abstract for Photochemical flow synthesis of 3-hydroxyazetidines

Journal article

Photochemical flow synthesis of 3-hydroxyazetidines

Ruggeri, M.; Dombrowski, A. W.; Djuric, S. W.; Baxendale, I. R.

ChemPhotoChem · 2019 · 3(12) · 1212–1218

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringPhotochemistry

A photo-flow Norrish-Yang cyclisation has been devised that delivers 3-hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemic…

Open DOIPDF
Cover of Chem. Eng. Tech.
Graphical abstract for A Robust and Scalable Continuous Flow Process for Glycerol Carbonate

Journal article

A Robust and Scalable Continuous Flow Process for Glycerol Carbonate

Mileghem, S. V.; De Borggraeve, W. M.; Baxendale, I. R.

Chem. Eng. Tech. · 2018 · 41(10) · 2014–2023

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

We report a robust continuous flow procedure for the synthesis of glycerol carbonate (2‐GLC) from green reagents glycerol and dimethyl carbonate (DMC), mediated by an inexpensive polymer‐supported base catalyst using methanol as co‐solvent. High conversion an…

Open DOIPDF