Route selection
Compare alternatives across chemistry, supply, safety, waste and delivery constraints.
Research area 02
Route design and process chemistry
From a plausible transformation to a safe, selective and transferable synthetic route.
Finding a reaction is only the beginning. The group evaluates chemistry as a connected route, considering starting materials, step count, selectivity, kinetics, hazards, work-up, impurity control, sustainability and translation to useful scale.
Scientific questions
Questions that shape the work
- 01
Which retrosynthetic route offers the best balance of feasibility, safety, cost and material efficiency?
- 02
What reaction variables determine selectivity, robustness and impurity formation?
- 03
Can operations be telescoped or redesigned to remove isolations and reduce waste?
- 04
How should a process be translated from discovery conditions into a practical operating window?
Established expertise
Demonstrated capabilities
Retrosynthetic route analysisRoute comparison and selectionKinetic and parameter profilingSolvent, reagent and catalyst assessmentImpurity understanding and controlTelescoping and sequence integrationProcess safety and hazard reductionBatch-to-flow translationGreen and efficiency metricsScale-up and technology transfer
Approach
How the problem is addressed
Process understanding
Map critical variables, failure modes and robust operating windows.
Translation
Connect laboratory performance with equipment, work-up and scale requirements.