Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

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Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

54 publications found for Immobilised reagents and scavengers

Cover of Synlett
Graphical abstract for A clean conversion of aldehydes to nitriles using a solid-supported hydrazine.

Journal article

A clean conversion of aldehydes to nitriles using a solid-supported hydrazine.

Baxendale, I. R.; Ley, S. V.; Sneddon, H. F.

Synlett · 2002 · (5) · 775–777

Immobilised reagents and scavengers

A polymer-supported hydrazine reagent has been applied to the conversion of a range of aldehydes to nitriles, providing a clean and efficient route to more diverse building blocks for combinatorial chemistry programmes.

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Cover of J. Chem. Soc. Perkin Trans. 1
Graphical abstract for A concise synthesis of carpanone using solid-supported reagents and scavengers.

Journal article

A concise synthesis of carpanone using solid-supported reagents and scavengers.

Baxendale, I. R.; Lee, A-L.; Ley, S. V.

J. Chem. Soc. Perkin Trans. 1 · 2002 · 16 · 1850–1857

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques. A new polymer-supported transition metal isomerisati…

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Cover of Synlett
Graphical abstract for A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds.

Journal article

A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds.

Baxendale, I. R.; Lee, A.-L.; Ley, S. V.

Synlett · 2002 · (3) · 516–518

Route design and process chemistryImmobilised reagents and scavengers

A polymer-supported iridium catalyst has been prepared and used in the isomerisation of the double bonds in aryl allylic derivatives with excellent trans selectivity and without the need for conventional work-up procedures.

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Cover of Synlett
Graphical abstract for Application of polymer-supported enzymes and reagents in the synthesis of gamma-aminobutyric acid (GABA) analogues.

Journal article

Application of polymer-supported enzymes and reagents in the synthesis of gamma-aminobutyric acid (GABA) analogues.

Baxendale, I. R.; Ernst, M.; Krahnert, W. R.; Ley, S. V.

Synlett · 2002 · (10) · 1641–1644

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Polymer-supported pig liver esterase was used for the resolution of meso-diesters. The enzyme can be recovered quantitatively from the reaction mixture by filtration and reused without significant loss of activity. Further transformation of the resulting enan…

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Cover of Nat. Rev. Drug Discovery
Graphical abstract for New tools and concepts for modern organic synthesis.

Journal article

New tools and concepts for modern organic synthesis.

Ley, S. V.; Baxendale, I. R.

Nat. Rev. Drug Discovery · 2002 · 1 · 573–586

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of …

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Cover of Chem. Rec.
Graphical abstract for Organic synthesis in a changing world.

Journal article

Organic synthesis in a changing world.

Ley, S. V.; Baxendale, I. R.

Chem. Rec. · 2002 · 2 · 377–388

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

This article is based on a lecture presented to the Chemical Society of Japan at Wasada University on March 27, 2002, by Professor Steven V. Ley. The lecture, “Organic Synthesis in a Changing World,” was a comprehensive account of the ongoing research efforts…

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Cover of Farmaco
Graphical abstract for Solid-supported reagents for multi-step organic synthesis: preparation and application.

Journal article

Solid-supported reagents for multi-step organic synthesis: preparation and application.

Ley, S. V.; Baxendale, I. R.; Brusotti, G.; Caldarelli, M.; Massi, A.; Nesi, M.

Farmaco · 2002 · 57 · 321–330

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Since the early days of combinatorial chemistry solid-phase organic synthesis has been the method of choice for the production of large libraries. Solution-phase synthesis is again gaining importance especially for the synthesis of parallel arrays of smaller,…

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Cover of J. Chem. Soc. Perkin Trans. 1
Graphical abstract for Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers.

Journal article

Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers.

Baxendale, I. R.; Brusotti, G.; Matsuoka, M.; Ley, S. V.

J. Chem. Soc. Perkin Trans. 1 · 2002 · NA · 143–154

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotin…

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Cover of Comb. Chem. & High Throughput Screening
Graphical abstract for Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents.

Journal article

Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents.

Baxendale, I. R.; Ley, S. V.; Nesi, M.; Lumeras, W.

Comb. Chem. & High Throughput Screening · 2002 · 5 · 197–199

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.

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Cover of Angew. Chem. Int. Ed.
Graphical abstract for Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions.

Journal article

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions.

Baxendale, I. R.; Ley S. V.; Piutti, C.

Angew. Chem. Int. Ed. · 2002 · 41 · 2194–2197

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

A sequence of polymer-supported reagents and scavengers was used to promote the synthetic transformations in the first total synthesis of (+)-plicamine (1), a member of the amaryllidaceae alkaloid family, starting from L-4-hydroxyphenylglycine.

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