Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Molecules
Graphical abstract for Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Journal article

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Baumann M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V.; Roper, K. A.

Molecules · 2014 · 19 · 9736–9759

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building b…

Open DOIPDF
Cover of Chem. Eur. J.
Graphical abstract for A Machine-Assisted Flow Synthesis of SR48692: a Probe for the Investigation of Neurotensin Receptor-1

Journal article

A Machine-Assisted Flow Synthesis of SR48692: a Probe for the Investigation of Neurotensin Receptor-1

Battilocchio, C.; Deadman, B. J.; Nikbin N.; Kitching, M. O.; Baxendale, I. R.; Ley, S. V.

Chem. Eur. J. · 2013 · 19 · 7917–7930

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported …

Open DOIPDF
Cover of Org. Biomol. Chem.
Graphical abstract for An Expeditious Synthesis of Imatinib and Analogues Utilising Flow Chemistry Methods

Journal article

An Expeditious Synthesis of Imatinib and Analogues Utilising Flow Chemistry Methods

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2013 · 11 · 1822–1839

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was…

Open DOIPDF
Cover of Green Process Synth.
Graphical abstract for Flow chemistry approaches directed at improving chemical synthesis

Journal article

Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I. R.; Mallia, C. J.; Brocken, L.

Green Process Synth. · 2013 · 2 · 211–230

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Flow synthesis offers many advantages when applied to the processing of difficult or dangerous chemical transformations. Furthermore, continuous production allows for rapid scale up of reactions without significant redevelopment of the routes. Importantly, it…

Open DOIPDF
Cover of Chem. Sci.
Graphical abstract for Flow Chemistry Synthesis of Zolpidem, Alpidem and other GABAA Agonists and their Biological Evaluation through the use of In-line Frontal Affinity Chromatography

Journal article

Flow Chemistry Synthesis of Zolpidem, Alpidem and other GABAA Agonists and their Biological Evaluation through the use of In-line Frontal Affinity Chromatography

Guetzoyan, L.; Nikbin, N.; Baxendale, I. R.; Ley S. V.

Chem. Sci. · 2013 · 4 · 764–769

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and aid information exchange have therefore clear value. Over the last few years, both synthetic chemistr…

Open DOIPDF
Cover of Synlett
Graphical abstract for Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Journal article

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Nakayama, K.; Browne, D. L.; Baxendale, I. R.; Ley, S. V.

Synlett · 2013 · 24(10) · 1298–1302

Flow chemistry and reaction engineering

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow c…

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Cover of Synlett
Graphical abstract for Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

Journal article

Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

Fernández, A.; Levine, Z. G.; Baumann, M.; Sulzer-Mossé, S.; Sparr, C.; Schläger, S.; Metzger, A.; Baxendale, I. R.; Ley, S. V.

Synlett · 2013 · 24(4) · 514–518

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

A new total synthesis of (-)-hennoxazole A is reported. The synthetic approach is based on the preparation of three similarly sized fragments resulting in a fast and convergent assembly of the natural product. The three key reactions of the synthesis include …

Open DOI
Cover of J. Chem. Technol. Biotechnol.
Graphical abstract for The integration of flow reactors into synthetic organic chemistry

Journal article

The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.

J. Chem. Technol. Biotechnol. · 2013 · 88 · 519–552

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The material presented in this review is based upon discussions and interactions with members of the Department of Chemistry and Biochemistry within the University of Windsor, Ontario, Canada. This article explores the changing face of chemical synthesis with…

Open DOIPDF
Cover of Org. Lett.
Graphical abstract for A "Catch–React–Release" Method for the FlowSynthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

Journal article

A "Catch–React–Release" Method for the FlowSynthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

Ingham, R. J.; Riva, E.; Nikbin, N.; Baxendale, I. R.; Ley, S. V.

Org. Lett. · 2012 · 14 · 3920–3923

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

The development of a monolith-supported synthetic procedure is reported, taking advantage of flow processing and the superior flow characteristics of monolithic reagents over gel-phase beads, to allow facile access to an important family of 2-aminopyrimidine …

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Cover of Org. Process Res. Dev.
Graphical abstract for A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

Journal article

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

Battilocchio, C.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.

Org. Process Res. Dev. · 2012 · 16 · 798–810

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

The development of a new, high-yielding, scalable and safe process for the preparation of 2-aminoadamantane-2-carboxylic acid (1) is described. This geminal, functionalized achiral amino acid has been reported to possess interesting biological activity as a t…

Open DOIPDF
Cover of Rapid Commun. Mass Spectrom.
Graphical abstract for Continuous flow reaction monitoring using an on-line miniature mass spectrometer

Journal article

Continuous flow reaction monitoring using an on-line miniature mass spectrometer

Browne, D. L.; Wright, S.; Deadman, B.; Dunnage, S.; Baxendale, I. R.; Turner, R.; Ley, S. V.

Rapid Commun. Mass Spectrom. · 2012 · 26 · 1999–2010

Flow chemistry and reaction engineeringAutomation and analyticsHazardous and reactive intermediates

A recently developed miniature electrospray ionisation mass spectrometer has been coupled to a preparative flow chemistry system in order to monitor reactive intermediates and competing reaction paths, screen starting materials, and optimise reaction conditio…

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Cover of Chem. Eur. J.
Graphical abstract for Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds

Journal article

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds

Zak, J.; Ron, D.; Riva, E.; Harding, H. P.; Cross, B. C. S.; Baxendale, I. R.

Chem. Eur. J. · 2012 · 32 · 9901–9910

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin-8-carbaldehydes are lacking. We describe here a high-yielding continuous flow synthesis that requires no manual intermediate purification or work-up, …

Open DOIPDF