Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

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Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

54 publications found for Immobilised reagents and scavengers

Cover of Chem. Commun.
Graphical abstract for A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Journal article

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Chem. Commun. · 2006 · NA · 4835–4837

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the m…

Open DOIPDF
Cover of Org. Lett.
Graphical abstract for Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Journal article

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Org. Lett. · 2006 · 8 · 5231–5234

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsImmobilised reagents and scavengers

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured …

Open DOIPDF
Cover of Eur. J. Chem.
Graphical abstract for Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Journal article

Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Eur. J. Chem. · 2006 · 12 · 4407–4416

Route design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCatTM) under microwave irradiation. The methodology has been used in both batch mode for classic…

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Cover of Org. Biomol. Chem.
Graphical abstract for A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Journal article

A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Siu, J.; Baxendale, I. R.; Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2005 · 3 · 3140–3160

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic ‘catch and release’ methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-b…

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Cover of Curr. Org. Chem.
Graphical abstract for Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Journal article

Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Baxendale, I. R.; Ley, I. R.

Curr. Org. Chem. · 2005 · 9 · 1521–1534

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase app…

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Cover of Ind. & Eng. Chem. Res.
Graphical abstract for Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Journal article

Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.

Ind. & Eng. Chem. Res. · 2005 · 44 · 8588–8592

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Two new naturally occurring amaryllidaceae alkaloids have been synthesized, using a divergent approach facilitated by the use of polymer-supported reagents and scavengers.

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Cover of Tetrahedron
Graphical abstract for The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Journal article

The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.; Martinelli, M.

Tetrahedron · 2005 · 61 · 5323–5349

Synthetic and heterocyclic chemistryRoute design and process chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydr…

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Cover of Chem. Euro. J.
Graphical abstract for Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Journal article

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Storer, R. I.; Takemoto, T.; Jackson, P.S.; Brown, D. S.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2004 · 10 · 2529–2547

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-…

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Cover of Heterocyles
Graphical abstract for Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Journal article

Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Baxendale, I. R.; Davidson, T. D.; Ley, S. V.; Perni, R. H.

Heterocyles · 2003 · 60 · 2707–2715

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials…

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