Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

53 publications found for Route design and process chemistry

Cover of Monatshefte für Chemie
Graphical abstract for Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing

Journal article

Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing

Aronow, J.; Stanetty, C.; Baxendale, I. R.; Mihovilovic, M. D.

Monatshefte für Chemie · 2018 · 150 · 11–19

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with cor…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimic

Journal article

A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.

Beilstein J. Org. Chem. · 2017 · 13 · 2549–2560

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described a…

Open DOIPDF
Cover of React. Chem. Eng.
Graphical abstract for Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

Journal article

Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

Brocken, L.; Price, P. D.; Whittaker, J.; Baxendale, I. R.

React. Chem. Eng. · 2017 · 2 · 662–668

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The free radical polymerisation of aqueous solutions of acrylic acid (1) has been studied using a continuous flow reactor to quickly screen reaction parameters such as temperature, residence time, monomer- and initiator concentration. The experimental data …

Open DOIPDF
Cover of Euro. J. Org. Chem.
Graphical abstract for Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Journal article

Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Kitching, M. O.; Dixon, O. E.; Baumann, M.; Baxendale, I. R.

Euro. J. Org. Chem. · 2017 · 44 · 6540–6553

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise diffi…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Journal article

Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Mallia, C. J.; Burton, P. M.; Smith, A. M. R.; Walter, G. C.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2016 · 12 · 1598–1607

Route design and process chemistryFlow chemistry and reaction engineering

A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has be…

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Cover of SynLett
Graphical abstract for Continuous Flow Synthesis of 2H-Azirines and their Diastereoselective Transformation to Aziridines

Journal article

Continuous Flow Synthesis of 2H-Azirines and their Diastereoselective Transformation to Aziridines

Baumann, M.; Baxendale, I. R.

SynLett · 2016 · 27 · 159–163

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-substitut…

Open DOIPDF
Cover of Org. Process Res. Dev.
Graphical abstract for Controlled Flow Precipitation as a Valuable Tool for Synthesis

Journal article

Controlled Flow Precipitation as a Valuable Tool for Synthesis

Filipponi, P.; Gioiello, A.; Baxendale, I. R.

Org. Process Res. Dev. · 2016 · 20 · 371–375

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an…

Open DOIPDF
Cover of Molecules
Graphical abstract for Exploring Flow Procedures for Diazonium Formation

Journal article

Exploring Flow Procedures for Diazonium Formation

Hu, T.; Baxendale, I. R.; Baumann, M.

Molecules · 2016 · 21 · 918–941

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including sev…

Open DOIPDF
Cover of React. Chem. Eng.
Graphical abstract for Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Journal article

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Holmes, N.; Akien, G. R.; Savage, R. J. D.; Stanetty, C.; Baxendale, I. R.; Blacker, A. J.; Taylor, B. A.; Woodward, R. L.; Meadows, R. E.; Bourne, R. A.

React. Chem. Eng. · 2016 · 1 · 96–100

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analytics

An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. Th…

Open DOIPDF
Cover of Euro. J. Org. Chem.
Graphical abstract for The Generation of a Library of Bromodomain Containing Protein Modulators Expedited by Continuous Flow Synthesis

Journal article

The Generation of a Library of Bromodomain Containing Protein Modulators Expedited by Continuous Flow Synthesis

Filipponi, P.; Baxendale, I. R.

Euro. J. Org. Chem. · 2016 · 11 · 2000–2012

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A continuous flow process delivering key building-blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor has emerged as a pivotal technology in both synthetic and isolation phases enabling the processing of slurries and s…

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Cover of Chem. Eng. Technol.
Graphical abstract for A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

Journal article

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

Baxendale, I. R.

Chem. Eng. Technol. · 2015 · 38 · 1713–1716

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The search for novel chemical architectures displaying improved biological properties is a never-ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occu…

Open DOIPDF
Cover of J. Pharm. Sci.
Graphical abstract for Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance

Journal article

Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance

Baxendale, I. R.; Braatz, R. D.; Hodnett, B. K.; Jensen, K. F.; Johnson, M. D.; Sharratt, P.; Sherlock J.-P.; Florence, A. J.

J. Pharm. Sci. · 2015 · 104 · 781–791

Synthetic and heterocyclic chemistryRoute design and process chemistry

This whitepaper highlights current challenges and opportunities associated with continuous synthesis, workup, and crystallization of active pharmaceutical ingredients (drug substances). We describe the technologies and requirements at each stage and emphasize…

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