Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

54 publications found for Immobilised reagents and scavengers

Cover of Chem. Euro. J.
Graphical abstract for A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Journal article

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2010 · 14 · 12342–12348

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

This article describes the design, optimisation and development of a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, a potent δ-opioid receptor agonist developed by AstraZeneca. The process employs a sequence of …

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Cover of Chem. Commun.
Graphical abstract for A flow-based synthesis of Imatinib: the API of Gleevec

Journal article

A flow-based synthesis of Imatinib: the API of Gleevec

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Chem. Commun. · 2010 · 46 · 2450–2452

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation.…

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Cover of Synlett
Graphical abstract for Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow Reactor

Journal article

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions using a Modular Flow Reactor

Baumann, M; Baxendale, I. R.; Ley, S. V.

Synlett · 2010 · (5) · 749–752

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the …

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Cover of Heterocycles
Graphical abstract for Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Journal article

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.

Heterocycles · 2010 · 82 · 1297–1316

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

We expand upon recent results concerning dipolar cycloaddition reactions of unstabilized azomethine ylids with nitro alkenes to generate 3-nitropyrrolidines via a flow chemistry sequence. This new work describes the development of a three-component coupling r…

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Cover of Org. Biomol. Chem.
Graphical abstract for The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Journal article

The Application of Flow Microreactors to the Preparation of a Family of Casein Kinase I Inhibitors

Venturoni, F.; Nikbin, N.; Ley S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1798–1806

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsHazardous and reactive intermediatesImmobilised reagents and scavengers

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particula…

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Cover of Org. Biomol. Chem.
Graphical abstract for The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using Microreactors

Journal article

The Continuous Flow Synthesis of Butane-2,3-Diacetal Protected Building Blocks Using Microreactors

Carter, C. C.; Lange, H.; Ley, S. V.; Baxendale, I. R.

Org. Biomol. Chem. · 2010 · 8 · 1588–1595

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA pro…

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Cover of Beilstein J. Org. Chem.
Graphical abstract for Continuous flow based catch and release protocol for the synthesis of a-Ketoesters

Journal article

Continuous flow based catch and release protocol for the synthesis of a-Ketoesters

Palmieri, A.; Ley, S. V.; Polyzos, A.; Ladlow, M.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2009 · 5(23) · 1–17

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of á-ketoesters is reported.

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Cover of J. Comb. Chem.
Graphical abstract for A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Journal article

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Baxendale, I. R.; Smith, C. D.; Voica, F.; Tamborini, L.; Ley, S. V.

J. Comb. Chem. · 2008 · 10 · 851–857

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent colu…

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Cover of Chimia
Graphical abstract for The Changing Face of Organic Synthesis

Journal article

The Changing Face of Organic Synthesis

Ley, S. V.; Baxendale, I. R.

Chimia · 2008 · 62 · 162–168

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors…

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Graphical abstract for Solid-Supported Reagents in Multi-Step Flow Synthesis

Book chapter

Solid-Supported Reagents in Multi-Step Flow Synthesis

Baxendale, I. R.; Ley, S. V.

New Avenues to Efficient Chemical Synthesis: Emerging Technologies (Ernst Schering Foundation Symposium Proceedings 2006-3.) · 2007 · Chapter 9 · 151–187

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The frequently overlooked benefits that considerably simplify and enrich our standard of living are most often hinged upon chemical synthesis. From the development of drugs in the ongoing fight against disease to the more aesthetic aspects of society with the…

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Cover of Org. Biomol. Chem.
Graphical abstract for [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Journal article

[3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith S. C.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1559–1561

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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Cover of Chem. Commun.
Graphical abstract for A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Journal article

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Chem. Commun. · 2006 · 24 · 2566–2568

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalys…

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