Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the archive and use research tags to move between publications and the group’s scientific programme.

Clear
Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

153 publications found for Synthetic and heterocyclic chemistry

Cover of Org. Biomol. Chem.
Graphical abstract for Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Journal article

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Siu, J.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2004 · 2 · 160–167

Synthetic and heterocyclic chemistry

The development of enhanced conditions for Lewis acid catalysed Leimgruber–Batcho indole synthesis using microwave acceleration is described.

Open DOIPDF
Cover of Chem. Euro. J.
Graphical abstract for Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Journal article

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Storer, R. I.; Takemoto, T.; Jackson, P.S.; Brown, D. S.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2004 · 10 · 2529–2547

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-…

Open DOIPDF
Graphical abstract for Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Book chapter

Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Ley, S. V.; Baxendale, I. R.; Grice, P.

Chemical Probes in Biology (NATO Science series) · 2003 · Series Volume 129 · 235–244

Synthetic and heterocyclic chemistryRoute design and process chemistry

The synthesis of organic compounds, especially biologically active molecules, is a very complex task involving many important decision making steps. These decisions are especially important at the synthesis planning stage where issues of regio-, chemo- and st…

Open DOIPDF
Cover of Heterocyles
Graphical abstract for Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Journal article

Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents.

Baxendale, I. R.; Davidson, T. D.; Ley, S. V.; Perni, R. H.

Heterocyles · 2003 · 60 · 2707–2715

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials…

Open DOIPDF
Cover of J. Chem. Soc. Perkin Trans. 1
Graphical abstract for A concise synthesis of carpanone using solid-supported reagents and scavengers.

Journal article

A concise synthesis of carpanone using solid-supported reagents and scavengers.

Baxendale, I. R.; Lee, A-L.; Ley, S. V.

J. Chem. Soc. Perkin Trans. 1 · 2002 · 16 · 1850–1857

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques. A new polymer-supported transition metal isomerisati…

Open DOIPDF
Cover of Synlett
Graphical abstract for Application of polymer-supported enzymes and reagents in the synthesis of gamma-aminobutyric acid (GABA) analogues.

Journal article

Application of polymer-supported enzymes and reagents in the synthesis of gamma-aminobutyric acid (GABA) analogues.

Baxendale, I. R.; Ernst, M.; Krahnert, W. R.; Ley, S. V.

Synlett · 2002 · (10) · 1641–1644

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Polymer-supported pig liver esterase was used for the resolution of meso-diesters. The enzyme can be recovered quantitatively from the reaction mixture by filtration and reused without significant loss of activity. Further transformation of the resulting enan…

Open DOIPDF
Cover of Nat. Rev. Drug Discovery
Graphical abstract for New tools and concepts for modern organic synthesis.

Journal article

New tools and concepts for modern organic synthesis.

Ley, S. V.; Baxendale, I. R.

Nat. Rev. Drug Discovery · 2002 · 1 · 573–586

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of …

Open DOIPDF
Cover of Chem. Rec.
Graphical abstract for Organic synthesis in a changing world.

Journal article

Organic synthesis in a changing world.

Ley, S. V.; Baxendale, I. R.

Chem. Rec. · 2002 · 2 · 377–388

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

This article is based on a lecture presented to the Chemical Society of Japan at Wasada University on March 27, 2002, by Professor Steven V. Ley. The lecture, “Organic Synthesis in a Changing World,” was a comprehensive account of the ongoing research efforts…

Open DOIPDF
Cover of Farmaco
Graphical abstract for Solid-supported reagents for multi-step organic synthesis: preparation and application.

Journal article

Solid-supported reagents for multi-step organic synthesis: preparation and application.

Ley, S. V.; Baxendale, I. R.; Brusotti, G.; Caldarelli, M.; Massi, A.; Nesi, M.

Farmaco · 2002 · 57 · 321–330

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Since the early days of combinatorial chemistry solid-phase organic synthesis has been the method of choice for the production of large libraries. Solution-phase synthesis is again gaining importance especially for the synthesis of parallel arrays of smaller,…

Open DOIPDF
Cover of J. Chem. Soc. Perkin Trans. 1
Graphical abstract for Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers.

Journal article

Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers.

Baxendale, I. R.; Brusotti, G.; Matsuoka, M.; Ley, S. V.

J. Chem. Soc. Perkin Trans. 1 · 2002 · NA · 143–154

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotin…

Open DOIPDF