Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

153 publications found for Synthetic and heterocyclic chemistry

Cover of Chem. Commun.
Graphical abstract for A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Journal article

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Chem. Commun. · 2006 · 24 · 2566–2568

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalys…

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Cover of Chem. Commun.
Graphical abstract for A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Journal article

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Chem. Commun. · 2006 · NA · 4835–4837

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the m…

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Cover of Org. Lett.
Graphical abstract for Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Journal article

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Org. Lett. · 2006 · 8 · 5231–5234

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsImmobilised reagents and scavengers

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured …

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Cover of Chimica Oggi, Chemistry Today
Graphical abstract for Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Journal article

Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Baxendale, I. R.; Pitts, M. R.

Chimica Oggi, Chemistry Today · 2006 · 24 · 41–45

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Microwave assisted chemistry is an increasingly important tool in the medicinal chemist’s quest to speed up drug development. With the development of commercial focussed-microwave reactors, reactions can be carried out safely and reproducibly at a useful labo…

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Cover of Synlett
Graphical abstract for Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process.

Journal article

Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process.

Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Synlett · 2006 · (3) · 427–430

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

This article describes the first enantioselective total synthesis of 2-aryl-2,3-dihydro-3-benzofurancarboxyamide neolignan, grossamide (1) using a fully automated and scalable flow reactor.

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Cover of Org. Biomol. Chem.
Graphical abstract for A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Journal article

A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Synthesis.

Siu, J.; Baxendale, I. R.; Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2005 · 3 · 3140–3160

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic ‘catch and release’ methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-b…

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Cover of Curr. Org. Chem.
Graphical abstract for Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Journal article

Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Baxendale, I. R.; Ley, I. R.

Curr. Org. Chem. · 2005 · 9 · 1521–1534

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase app…

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Cover of Ind. & Eng. Chem. Res.
Graphical abstract for Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Journal article

Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.

Ind. & Eng. Chem. Res. · 2005 · 44 · 8588–8592

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Two new naturally occurring amaryllidaceae alkaloids have been synthesized, using a divergent approach facilitated by the use of polymer-supported reagents and scavengers.

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Cover of Tetrahedron
Graphical abstract for The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Journal article

The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.; Martinelli, M.

Tetrahedron · 2005 · 61 · 5323–5349

Synthetic and heterocyclic chemistryRoute design and process chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydr…

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