Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

153 publications found for Synthetic and heterocyclic chemistry

Cover of Org. Biomol. Chem.
Graphical abstract for Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal Tartrates

Journal article

Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane-2,3-Diacetal Tartrates

Carter, C. F.; Baxendale, I. R.; O’Brien, M.; Pavey, J. B. J.; Ley, S. V.

Org. Biomol. Chem. · 2009 · 7 · 4594–4597

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocols.

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Cover of J. Comb. Chem.
Graphical abstract for A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Journal article

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor.

Baxendale, I. R.; Smith, C. D.; Voica, F.; Tamborini, L.; Ley, S. V.

J. Comb. Chem. · 2008 · 10 · 851–857

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent colu…

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Cover of Synthesis
Graphical abstract for A New Focused Microwave Approach to Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-component Coupling Process

Journal article

A New Focused Microwave Approach to Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-component Coupling Process

Hopkin, M. D.; Baxendale, I. R.; Ley, S. V.

Synthesis · 2008 · (11) · 1688–1702

Synthetic and heterocyclic chemistryPhotochemistry

A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their form…

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Graphical abstract for Organic Chemistry in Microreactors; Heterogenous Reactions

Book chapter

Organic Chemistry in Microreactors; Heterogenous Reactions

Baxendale, I. R.; Hayward, J. J.; Lanners, S.; Ley, S. V.; Smith, C. D.

Microreactors in Organic Chemistry and Catalysis · 2008 · Chapter 4.2 · 84–121

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

Modern organic synthesis is undergoing a period of rapid change due to the many demands challenging it today. The need for greater speed in the discovery process requires high‑throughput methods and inevitably more advanced automation. However, safety factors…

Cover of Chimia
Graphical abstract for The Changing Face of Organic Synthesis

Journal article

The Changing Face of Organic Synthesis

Ley, S. V.; Baxendale, I. R.

Chimia · 2008 · 62 · 162–168

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

The article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors…

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Cover of Org. Proc. Res. Dev.
Graphical abstract for A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Journal article

A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis

Hornung, C. H.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.

Org. Proc. Res. Dev. · 2007 · 11 · 399–405

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

This paper reports proof of concept, development, and trials for a novel plastic microcapillary flow disc (MFD) reactor. The MFD was constructed from a flexible, plastic microcapillary film (MCF), comprising parallel capillary channels with diameters in the r…

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Cover of Org. Biomol. Chem.
Graphical abstract for Batch and Flow Mode Focused Microwave Synthesis of 5-Amino-4-cyanopyrazoles and their Further Conversion to 4-amino-pyrazolopyrimidines.

Journal article

Batch and Flow Mode Focused Microwave Synthesis of 5-Amino-4-cyanopyrazoles and their Further Conversion to 4-amino-pyrazolopyrimidines.

Smith, C. J.; Iglesias-Sigüenza, J.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 2758–2761

Synthetic and heterocyclic chemistry

A new approach to the synthesis of 5-amino-4-cyanopyrazoles has been developed, utilising a novel flow microwave device. These products are then converted by a batch mode microwave process to structurally more complex dimeric and ‘mixed’ pyrazolopyrimidine st…

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Cover of Combinatorial Chemistry & High Throughput Screening
Graphical abstract for Microwave Reactions under Continuous Flow Conditions.

Journal article

Microwave Reactions under Continuous Flow Conditions.

Baxendale, I. R.; Hayward, J. J.; Ley. S. V.

Combinatorial Chemistry & High Throughput Screening · 2007 · 10 · 802–836

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringPhotochemistry

Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered to…

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Graphical abstract for Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools

Book chapter

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools

Ley, S. V.; Baxendale, I. R.; Longbottom D. A.; Myers, R. M.

In Drug Discovery & Development · 2007 · Chapter 2 · 51–91

Synthetic and heterocyclic chemistry

The natural world inspires us all; from artist and philosopher to biologist and chemist alike. In our quest for new knowledge, the exquisite and varied architectures of natural products provide a rich pallet for discovery. Whether these are used to probe biol…

Graphical abstract for Solid-Supported Reagents in Multi-Step Flow Synthesis

Book chapter

Solid-Supported Reagents in Multi-Step Flow Synthesis

Baxendale, I. R.; Ley, S. V.

New Avenues to Efficient Chemical Synthesis: Emerging Technologies (Ernst Schering Foundation Symposium Proceedings 2006-3.) · 2007 · Chapter 9 · 151–187

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The frequently overlooked benefits that considerably simplify and enrich our standard of living are most often hinged upon chemical synthesis. From the development of drugs in the ongoing fight against disease to the more aesthetic aspects of society with the…

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Cover of Org. Biomol. Chem.
Graphical abstract for Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Journal article

Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process

Smith, C. D.; Baxendale, I. R.; Tranmer, G. K.; Baumann, M.; Smith, S. C.; Russell A. Lewthwaite, R. A.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1562–1568

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and…

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Cover of Org. Biomol. Chem.
Graphical abstract for [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Journal article

[3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith S. C.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1559–1561

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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