Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Org. Biomol. Chem.
Graphical abstract for [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Journal article

[3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith S. C.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1559–1561

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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Cover of Chem. Commun.
Graphical abstract for A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Journal article

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Chem. Commun. · 2006 · 24 · 2566–2568

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalys…

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Cover of Chem. Commun.
Graphical abstract for A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Journal article

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Chem. Commun. · 2006 · NA · 4835–4837

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the m…

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Cover of Org. Lett.
Graphical abstract for Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Journal article

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.

Org. Lett. · 2006 · 8 · 5231–5234

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analyticsImmobilised reagents and scavengers

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured …

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Cover of Eur. J. Chem.
Graphical abstract for Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Journal article

Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations.

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Eur. J. Chem. · 2006 · 12 · 4407–4416

Route design and process chemistryFlow chemistry and reaction engineeringPhotochemistryImmobilised reagents and scavengers

This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCatTM) under microwave irradiation. The methodology has been used in both batch mode for classic…

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Cover of Chimica Oggi, Chemistry Today
Graphical abstract for Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Journal article

Microwave Flow Chemistry: The Next Evolutionary Step in Synthetic Chemistry

Baxendale, I. R.; Pitts, M. R.

Chimica Oggi, Chemistry Today · 2006 · 24 · 41–45

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Microwave assisted chemistry is an increasingly important tool in the medicinal chemist’s quest to speed up drug development. With the development of commercial focussed-microwave reactors, reactions can be carried out safely and reproducibly at a useful labo…

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Cover of Synlett
Graphical abstract for Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process.

Journal article

Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process.

Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.

Synlett · 2006 · (3) · 427–430

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

This article describes the first enantioselective total synthesis of 2-aryl-2,3-dihydro-3-benzofurancarboxyamide neolignan, grossamide (1) using a fully automated and scalable flow reactor.

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Cover of J. Comb. Chem.
Graphical abstract for Formation of 4-Aminopyrimidines via the Trimerization of Nitriles using Focused Microwave Heating.

Journal article

Formation of 4-Aminopyrimidines via the Trimerization of Nitriles using Focused Microwave Heating.

Baxendale, I. R.; Ley, S. V.

J. Comb. Chem. · 2005 · 7 · 483–489

Flow chemistry and reaction engineering

A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantiti…

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