Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Org. Lett.
Graphical abstract for Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Journal article

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Martin, L. J.; Marzinzik, A. L.; Ley, S. V.; Baxendale, I. R.

Org. Lett. · 2011 · 13 · 320–323

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases…

Open DOIPDF
Cover of Synlett
Graphical abstract for Syngas Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Journal article

Syngas Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Kasinathan, S.; Bourne,S. L.; Tolstoy, P.; Koos, P.; O'Brien, M.; Bates, R. W.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (18) · 2648–2651

Flow chemistry and reaction engineering

We report a continuous flow, rhodium-catalysed hydroformylation of various styrenes using a tube-in-tube gas-liquid reactor. The flow process afforded selectively branched aryl aldehydes in good yields.

Open DOIPDF
Cover of ACS Comb. Sci.
Graphical abstract for Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Journal article

Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.

ACS Comb. Sci. · 2011 · 13 · 405–413

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisubstituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structur…

Open DOIPDF
Cover of Org. Biomol. Chem.
Graphical abstract for Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Journal article

Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Koos, P.; Gross, U.; Polyzos, A.; O'Brien, M.; Baxendale, I. R.; Ley, S. V.

Org. Biomol. Chem. · 2011 · 9 · 6903–6908

Flow chemistry and reaction engineeringHazardous and reactive intermediates

We report on the development of a continuous flow process for the palladium catalysed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of c…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Journal article

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Roper, K. A.; Lange, H.; Polyzos, A.; Berry, M. B.; Baxendale, I. R.; Ley, S. V.

Beilstein J. Org. Chem. · 2011 · 7 · 1648–1655

Flow chemistry and reaction engineering

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line pu…

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Cover of Angew. Chem. Int. Ed.
Graphical abstract for The Continuous Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas-Permeable Membrane Reactor

Journal article

The Continuous Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas-Permeable Membrane Reactor

Polyzos A.; O'Brien M.; Petersen T. P.; Baxendale I. R.; Ley S. V.

Angew. Chem. Int. Ed. · 2011 · 49 · 1190–1193

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

Keep it simple: A gas-liquid flow reactor has been developed based on a gas permeable tube-in-tube configuration which effectively delivers gas to a liquid substrate stream in a safe, continuous fashion. A series of carboxylic acids were prepared from the rea…

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Cover of Synlett
Graphical abstract for The Continuous-Flow Synthesis of Styrenes using Ethylene in a Palladium Catalysed Heck Cross-Coupling Reaction

Journal article

The Continuous-Flow Synthesis of Styrenes using Ethylene in a Palladium Catalysed Heck Cross-Coupling Reaction

Bourne, S. L.; Koos, P.; O'Brien,M.; Martin,B.; Schenkel, B.; Baxendale, I. R.; Ley, S. V.

Synlett · 2011 · (18) · 2643–2647

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

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Cover of Mol. Diversity
Graphical abstract for The Flow Synthesis of Heterocycles for Natural Product and Medicinal Chemistry Applications

Journal article

The Flow Synthesis of Heterocycles for Natural Product and Medicinal Chemistry Applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.

Mol. Diversity · 2011 · 15 · 615–630

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we d…

Open DOIPDF
Cover of Chem. Euro. J.
Graphical abstract for A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Journal article

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR analysis for the Preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and highly Selective D-opioid Receptor

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2010 · 14 · 12342–12348

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringImmobilised reagents and scavengers

This article describes the design, optimisation and development of a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, a potent δ-opioid receptor agonist developed by AstraZeneca. The process employs a sequence of …

Open DOIPDF
Cover of Synlett
Graphical abstract for A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Journal article

A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.

Synlett · 2010 · (4) · 505–508

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

This article describes the continuous flow synthesis of ­6-methoxy-8-(4-methyl-1,4-diazepan-1-yl)-N-(4-morpholinophen-yl)-4-oxo-1,4-dihydroquinoline-2-carboxamide, a potent 5HT1B antagonist developed by AstraZeneca.

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Cover of Ind. & Eng. Chem. Res.
Graphical abstract for A multiple microcapillary reactor for organic synthesis

Journal article

A multiple microcapillary reactor for organic synthesis

Hornung, C. H.; Hallmark, B.; Baumann, M.; Baxendale, I. R.; Ley, S. V.; Hester, P.; Clayton, P.; Mackley, M. R.

Ind. & Eng. Chem. Res. · 2010 · 49 · 4576–4582

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

This paper presents process characteristics and proof of concept reactions for a newly developed microreactor system, termed the Cambridge Disc Microreactor (CDM), using plastic microcapillary flow discs (MFDs). These flat reactor discs were constructed from …

Open DOIPDF
Cover of Adv. Synth. Catal.
Graphical abstract for A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation

Journal article

A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation

Hornung, C. H.; Hallmark, B.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.

Adv. Synth. Catal. · 2010 · 352 · 1736–1745

Flow chemistry and reaction engineeringHazardous and reactive intermediates

Herein we describe the preparation of a novel continuous flow multi-channel microreactor in which the internal surface has been functionalised with a palladium coating, enabling its use in catalytic heterogeneous liquid-phase reactions. Simple chemical depos…

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