Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

53 publications found for Route design and process chemistry

Cover of Curr. Org. Chem.
Graphical abstract for Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Journal article

Synthesis of Alkaloid Natural Products using Supported Reagents and Scavengers

Baxendale, I. R.; Ley, I. R.

Curr. Org. Chem. · 2005 · 9 · 1521–1534

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase app…

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Cover of Tetrahedron
Graphical abstract for The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Journal article

The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.; Martinelli, M.

Tetrahedron · 2005 · 61 · 5323–5349

Synthetic and heterocyclic chemistryRoute design and process chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydr…

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Cover of Chem. Euro. J.
Graphical abstract for Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Journal article

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C.

Storer, R. I.; Takemoto, T.; Jackson, P.S.; Brown, D. S.; Baxendale, I. R.; Ley, S. V.

Chem. Euro. J. · 2004 · 10 · 2529–2547

Synthetic and heterocyclic chemistryRoute design and process chemistryImmobilised reagents and scavengers

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-…

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Graphical abstract for Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Book chapter

Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

Ley, S. V.; Baxendale, I. R.; Grice, P.

Chemical Probes in Biology (NATO Science series) · 2003 · Series Volume 129 · 235–244

Synthetic and heterocyclic chemistryRoute design and process chemistry

The synthesis of organic compounds, especially biologically active molecules, is a very complex task involving many important decision making steps. These decisions are especially important at the synthesis planning stage where issues of regio-, chemo- and st…

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Cover of Synlett
Graphical abstract for A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds.

Journal article

A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds.

Baxendale, I. R.; Lee, A.-L.; Ley, S. V.

Synlett · 2002 · (3) · 516–518

Route design and process chemistryImmobilised reagents and scavengers

A polymer-supported iridium catalyst has been prepared and used in the isomerisation of the double bonds in aryl allylic derivatives with excellent trans selectivity and without the need for conventional work-up procedures.

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