Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

30 publications found for Hazardous and reactive intermediates

Cover of Angew. Chem. Int. Ed.
Graphical abstract for Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Journal article

Multi-Step Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Baxendale, I. R.; Ley, S. V.; Mansfield, A. C.; Smith, C. D.

Angew. Chem. Int. Ed. · 2009 · 48 · 4017–4021

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed …

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Cover of Org. Biomol. Chem.
Graphical abstract for A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process

Journal article

A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.; Tierney, J. P.

Org. Biomol. Chem. · 2008 · 6 · 1577–1586

Flow chemistry and reaction engineeringHazardous and reactive intermediates

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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Cover of Org. Biomol. Chem.
Graphical abstract for Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions

Journal article

Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.

Org. Biomol. Chem. · 2008 · 6 · 1587–1593

Flow chemistry and reaction engineeringHazardous and reactive intermediates

The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs.

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Cover of Org. Biomol. Chem.
Graphical abstract for [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Journal article

[3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3-Triazoles in a Modular Flow Reactor

Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith S. C.; Ley, S. V.

Org. Biomol. Chem. · 2007 · 5 · 1559–1561

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediatesImmobilised reagents and scavengers

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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Cover of Tetrahedron
Graphical abstract for The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Journal article

The Rapid Preparation of 5-Substituted-2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Scavengers

Baxendale, I. R.; Ley, S. V.; Martinelli, M.

Tetrahedron · 2005 · 61 · 5323–5349

Synthetic and heterocyclic chemistryRoute design and process chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydr…

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Cover of Green Chem.
Graphical abstract for The Clean and Efficient Synthesis of Azo-Dyes Using Polymer-Supported Reagents.

Journal article

The Clean and Efficient Synthesis of Azo-Dyes Using Polymer-Supported Reagents.

Caldarelli, M.; Baxendale, I. R.; Ley, S. V.

Green Chem. · 2000 · 2 · 43–45

Synthetic and heterocyclic chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

The recent technological advancements in polymer-supported reactions have led to the propagation of combinatorial chemistry as a method for the rapid and efficient preparation of novel functionalised molecules. An interesting and fast growing branch of this a…

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