Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

Research record

Publications

Search the archive and use research tags to move between publications and the group’s scientific programme.

Clear
Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

104 publications found for Flow chemistry and reaction engineering

Cover of Flow Chemistry for the Synthesis of Heterocycles
Graphical abstract for Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Book chapter

Flow Chemistry Approaches Applied to the Synthesis of Saturated Heterocycles

Baumann, M.; Baxendale, I. R.

Flow Chemistry for the Synthesis of Heterocycles · 2018 · 187–236

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Continuous flow processing approaches are having a significant impact on the way we devise and perform chemical synthesis. Flow chemistry has repeatedly demonstrated numerous improvements with respect to synthesis efficiency, process safety and ease of reacti…

Open DOI
Cover of React. Chem. Eng.
Graphical abstract for Flow synthesis of coumalic acid and its derivatization

Journal article

Flow synthesis of coumalic acid and its derivatization

Smith, L. K.; Baxendale, I. R.

React. Chem. Eng. · 2018 · 3 · 722–732

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineering

Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address wit…

Open DOIPDF
Cover of Monatshefte für Chemie
Graphical abstract for Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing

Journal article

Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing

Aronow, J.; Stanetty, C.; Baxendale, I. R.; Mihovilovic, M. D.

Monatshefte für Chemie · 2018 · 150 · 11–19

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with cor…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimic

Journal article

A concise flow synthesis of indole-3 carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.

Beilstein J. Org. Chem. · 2017 · 13 · 2549–2560

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described a…

Open DOIPDF
Cover of Euro. J. Org. Chem.
Graphical abstract for A Continuous Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of New Etomidate Derivatives

Journal article

A Continuous Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of New Etomidate Derivatives

Baumann, M.; Baxendale, I. R.

Euro. J. Org. Chem. · 2017 · 44 · 6518–6524

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

A simple yet robust flow set-up for the efficient desulfurization of a series of thioimidazoles is presented generating the corresponding imidazole derivatives in high yields. The strategic choice of peristaltic over piston pumps allowed reliable delivery of …

Open DOIPDF
Cover of Biorg. Med. Chem.
Graphical abstract for A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

Journal article

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

Baumann, M.; Baxendale, I. R.

Biorg. Med. Chem. · 2017 · 25 · 6218–6223

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringHazardous and reactive intermediates

A continuous flow process is presented that enables the efficient synthesis and derivatization of 1,2,4-thiadiazole heterocycles. Special attention was given to the safe handling of the versatile yet hazardous trichloromethane sulfenylchloride reagent includi…

Open DOIPDF
Cover of React. Chem. Eng.
Graphical abstract for Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

Journal article

Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

Brocken, L.; Price, P. D.; Whittaker, J.; Baxendale, I. R.

React. Chem. Eng. · 2017 · 2 · 662–668

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

The free radical polymerisation of aqueous solutions of acrylic acid (1) has been studied using a continuous flow reactor to quickly screen reaction parameters such as temperature, residence time, monomer- and initiator concentration. The experimental data …

Open DOIPDF
Cover of Euro. J. Org. Chem.
Graphical abstract for Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Journal article

Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Kitching, M. O.; Dixon, O. E.; Baumann, M.; Baxendale, I. R.

Euro. J. Org. Chem. · 2017 · 44 · 6540–6553

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise diffi…

Open DOIPDF
Cover of Org. Proc. Res. Dev.
Graphical abstract for Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Journal article

Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Baumann, M.; Baxendale, I. R.; Filipponi, P.; Hu, T.

Org. Proc. Res. Dev. · 2017 · 21 · 2052–2059

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringAutomation and analytics

A flow based multistep processing sequence to reliably provide the delivery of a highly functional cyclopentenone is described. The exemplification of employing solid dosing of reagents and in-line aqueous extraction has enabled an integrated workflow in a hi…

Open DOIPDF
Cover of Beilstein J. Org. Chem.
Graphical abstract for Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Journal article

Catalytic Chan—Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Mallia, C. J.; Burton, P. M.; Smith, A. M. R.; Walter, G. C.; Baxendale, I. R.

Beilstein J. Org. Chem. · 2016 · 12 · 1598–1607

Route design and process chemistryFlow chemistry and reaction engineering

A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has be…

Open DOIPDF
Cover of SynLett
Graphical abstract for Continuous Flow Synthesis of 2H-Azirines and their Diastereoselective Transformation to Aziridines

Journal article

Continuous Flow Synthesis of 2H-Azirines and their Diastereoselective Transformation to Aziridines

Baumann, M.; Baxendale, I. R.

SynLett · 2016 · 27 · 159–163

Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineering

Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-substitut…

Open DOIPDF
Cover of React. Chem. Eng.
Graphical abstract for Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

Journal article

Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

Baumann, M.; Baxendale, I. R.

React. Chem. Eng. · 2016 · 1 · 147–150

Synthetic and heterocyclic chemistryFlow chemistry and reaction engineeringPhotochemistry

A new enabling technology for performing photochemical reactions in a continuous fashion is presented. This photo-reactor is compatible with existing flow systems and can be furthermore linked to a photo-spectrometer in order to allow for real time analysis o…

Open DOIPDF