Baxendale GroupAdvanced synthetic chemistry, engineered for scaleDepartment of Chemistry

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Publications

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Synthetic and heterocyclic chemistryRoute design and process chemistryFlow chemistry and reaction engineeringAutomation and analyticsPhotochemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

54 publications found for Immobilised reagents and scavengers

Cover of Tetrahedron
Graphical abstract for Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents.

Journal article

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents.

Baxendale, I. R.; Ley, S. V.; Nesi, M.; Piutti, C.

Tetrahedron · 2002 · 58 · 6285–6304

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

In this report we describe in full the total synthesis of the amaryllidaceae alkaloid (+)-plicamine 1 including a model compound study. In both cases the compounds were prepared using solid-supported reagents and scavengers in multi-step sequences of reaction…

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Cover of Synlett
Graphical abstract for A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers.

Journal article

A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers.

Baxendale, I. R.; Lee, A.-L.; Ley, S. V.

Synlett · 2001 · (9) · 1482–1484

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques.

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Cover of J. Chem. Soc., Perkin Trans. 1
Graphical abstract for Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Journal article

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Ley, S. V.; Baxendale, I. R.; Bream, R. N.; Jackson, P. S.; Leach, A. G.; Longbottom, D. A.; Nesi, M.; Scott, J. S.; Storer, R. Ian; Talyor, S. J.

J. Chem. Soc., Perkin Trans. 1 · 2000 · (23) · 3815–4196

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

The use of polymer-supported reagents and scavengers provides an attractive and practical method for the clean and efficient preparation of novel chemical libraries with potential application in the pharmaceutical or agrochemical industries. These methods…

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Cover of Bioorg. Med. Chem. Lett.
Graphical abstract for Polymer-Supported Reagents for Multi-Step Organic Synthesis: Application to the Synthesis of Sildenafil.

Journal article

Polymer-Supported Reagents for Multi-Step Organic Synthesis: Application to the Synthesis of Sildenafil.

Baxendale, I. R.; Ley, S. V.

Bioorg. Med. Chem. Lett. · 2000 · 10 · 1983–1986

Synthetic and heterocyclic chemistryImmobilised reagents and scavengers

Sildenafil 1 (Viagra™), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purifi…

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Cover of Green Chem.
Graphical abstract for The Clean and Efficient Synthesis of Azo-Dyes Using Polymer-Supported Reagents.

Journal article

The Clean and Efficient Synthesis of Azo-Dyes Using Polymer-Supported Reagents.

Caldarelli, M.; Baxendale, I. R.; Ley, S. V.

Green Chem. · 2000 · 2 · 43–45

Synthetic and heterocyclic chemistryHazardous and reactive intermediatesImmobilised reagents and scavengers

The recent technological advancements in polymer-supported reactions have led to the propagation of combinatorial chemistry as a method for the rapid and efficient preparation of novel functionalised molecules. An interesting and fast growing branch of this a…

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